XRCC1
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Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 1
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Overview
The X-ray repair cross complementing protein 1 (XRCC1) is a DNA repair protein important in both single strand break repair and base excision repair following damage from ionizing radiation and alkylating agents. XRCC1 acts as a scaffold protein to coordi -
Synonyms
XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; RCC; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
XRCC1 involved in several pathways and played different roles in them. We selected most pathways XRCC1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | TDG;POLE2;APEX2;PCNA;POLE3;PNKP;LIG3;XRCC1;LIG1 |
XRCC1 has several biochemical functions, for example, damaged DNA binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC1 itself. We selected most functions XRCC1 had, and list some proteins which have the same functions with XRCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| damaged DNA binding | GTF2H3;TP53BP1;TRPC2;RPA2;BRCA1;RPA3;HMGB1;RPS3;CRY-DASH |
| enzyme binding | UBE2I;HSPA8;GSTM1;SIRT3;CTNNBL1;CALU;PARP1;HDAC3;MAPK8 |
| protein binding | POP7;FAM98A;LACTB2;AP2M1;IYD;SGCG;GSS;MAP3K7IP3;ZC3H8 |
XRCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC1.
APTX; PNKP
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that XRCC1 recombinant protein can interact with other proteins, such as DNA polymerase and other DNA repair enzymes, to participate in the DNA repair process.
The current treatments for XRCC1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for DNA repair process.
Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of XRCC1 recombinant protein in vivo. These animal models can be used to study the effects of XRCC1 recombinant protein on tumorigenesis, development, and metastasis.
Studies have shown that XRCC1 recombinant protein plays an important role in the development and progression of tumors, especially related to DNA repair defects and abnormal cell proliferation.
By detecting the expression level and modification status of XRCC1 recombinant protein, it can be used to diagnose certain tumor diseases. In addition, XRCC1 recombinant protein may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.
In the experiment, the XRCC1 gene can be introduced into the expression vector by gene cloning technology, and then the XRCC1 recombinant protein can be expressed in Escherichia coli or eukaryotic cells.
Customer Reviews (3)
Write a reviewIt is extremely safe and has not been found to have any side effects after long-term use.
The performance of this one is very stable and the price is reasonable, I would definitely buy this product again.
Easy to operate and easy to use, would recommend it to others.
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