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XRCC5

  • Official Full Name

    X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

  • Overview

    X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.
  • Synonyms

    XRCC5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5; KARP 1; Ku autoantigen; 80kDa; KU80; Ku86; KUB2; TLAA; CTC85; CTCBF; nuclear factor IV; Ku autoantigen, 80kDa; DNA repair protein XRCC5; thyroid-lupus autoantigen; 86 kDa subunit of Ku antigen; lupus Ku autoantigen protein p86; Ku86 autoantigen related protein 1; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; NFIV; KARP1; KARP-1; FLJ39089;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XRCC5-29197TH Recombinant Human XRCC5, His-tagged E.coli His
Human XRCC5-3758H Recombinant Human XRCC5, GST-tagged E.coli GST 384-732aa
Human XRCC5-8228H Recombinant Human XRCC5 protein, His-tagged E.coli His Val2~Ser460
Human XRCC5-1798H Recombinant Human XRCC5, His tagged Insect Cell His
Human XRCC5-149H Recombinant Human XRCC5 protein, His-tagged Insect Cell His
Human XRCC5-1549H Recombinant Human XRCC5 protein E.coli N/A
Human XRCC5 & XRCC6-543HCL Recombinant Human XRCC5 & XRCC6 cell lysate Insect Cell N/A
Human XRCC5-254HCL Recombinant Human XRCC5 293 Cell Lysate HEK293 N/A
Human XRCC5-3556H Recombinant Human XRCC5 protein, His-tagged E.coli His 384-732 aa
Human XRCC5-2265H Recombinant Human XRCC5 protein, MBP&His-tagged Insect Cell MBP&His 251-455aa
Human XRCC5-3774H Recombinant Human XRCC5 protein, His&Myc-tagged E.coli His&Myc 251-455aa
Human XRCC5-6579H Recombinant Human XRCC5 Protein (Leu384-Ile732), N-His tagged E.coli N-His Leu384-Ile732
Human XRCC5-2646H Recombinant Human XRCC5 protein(571-730 aa), C-His-tagged E. coli C-His 571-730 aa
Human XRCC5-3773H Recombinant Human XRCC5 protein, His-tagged E.coli His 251-455aa
Mouse XRCC5-18639M Recombinant Mouse XRCC5 Protein Mammalian Cell His
Mouse Xrcc5-8229M Recombinant Mouse Xrcc5 protein, His & T7-tagged E.coli His/T7 Leu251~Ile732 (Accession # P27641)
Mouse XRCC5-10243M Recombinant Mouse XRCC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse XRCC5-10243M-B Recombinant Mouse XRCC5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque XRCC5-5233R Recombinant Rhesus monkey XRCC5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque XRCC5-5046R-B Recombinant Rhesus Macaque XRCC5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque XRCC5-5046R Recombinant Rhesus Macaque XRCC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish XRCC5-2317Z Recombinant Zebrafish XRCC5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XRCC5 Related Research Area

XRCC5 involved in several pathways and played different roles in them. We selected most pathways XRCC5 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Non-homologous end-joiningPOLM;XRCC5;FEN1;XRCC4;POLL;DNTT;XRCC6;DCLRE1C;PRKDC

XRCC5 has several biochemical functions, for example, contributes_to 5-deoxyribose-5-phosphate lyase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC5 itself. We selected most functions XRCC5 had, and list some proteins which have the same functions with XRCC5. You can find most of the proteins on our site.

Function Related Protein
contributes_to 5-deoxyribose-5-phosphate lyase activity
ATP bindingAtp8a2;PYGL;P2RX5;PDS5B;RNASEL;ROR2;GARS;P2RX8;AKT1
ATP-dependent DNA helicase activityRUVBL2;BLM;ERCC3;RTEL1;ERCC2;CHD2;GTF2H4;BRIP1;FBXO18
DNA bindingIRX4A;FOXE1;STRBP;H2BFWT;ZNF426;SMAD5;ZNF692;FLI1A;NFE2L2A
damaged DNA bindingBRCA1;REV1;XPA;TRP53;ERCC4;DCLRE1C;CRY-DASH;FEN1;POLB
double-stranded DNA bindingFEN1;MRE11A;TRP63;XRCC5;NKX2-8;TDP1;TP73;SAFB;LSM14A
contributes_to double-stranded telomeric DNA bindingXRCC5;XRCC6
poly(A) RNA bindingFMR1;RBM15;THOC4;RBM47;FTSJ3;GRN;ANP32A;TSFM;NME1
protein C-terminus bindingHIC2;NIPBL;MKI67;ERCC2;PIAS4;SDC1;ATXN2;YWHAB;TBL1X
protein bindingLZTS2;FBXL14;TRAF6;BRAP;APOOL;CD4;SERBP1;EFCAB4A;MAGI2
telomeric DNA bindingTEN1;TINF2;NCL;HNRNPD;TERFA;XRCC5;SMG6;TP53BP1;PIF1
transcription regulatory region DNA bindingZFP382;MEF2C;FOXM1;TFEB;SMAD4;NR1D1;TBL1XR1;RBBP5;TFAP2A
ubiquitin protein ligase bindingATP6V0C;LRPPRC;GPR19;MUL1;TOLLIP;PARK2;ANKRD32;UBE2V1;TNFRSF1B

XRCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC5.

XRCC6; WRN

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does XRCC5 function in DNA repair? 10/02/2022

XRCC5 forms a heterodimer with XRCC6 (Ku70) and plays a crucial role in non-homologous end joining (NHEJ) repair of DNA double-strand breaks.

What are the clinical implications of XRCC5 mutations? 07/27/2022

Mutations in XRCC5 have been associated with an increased risk of cancer and may affect the response to certain cancer treatments.

Are there diagnostic tests to detect XRCC5 mutations? 03/27/2019

Yes, genetic testing can identify XRCC5 mutations, which can be important for assessing cancer risk.

Can XRCC5 mutations lead to cancer susceptibility? 03/31/2018

Yes, mutations in XRCC5 have been linked to an increased susceptibility to certain types of cancer, such as breast and ovarian cancer.

How can XRCC5 be targeted in cancer therapy? 01/24/2018

XRCC5 inhibitors are being investigated as potential cancer therapeutics to sensitize cancer cells to radiation and chemotherapy.

Customer Reviews (3)

Write a review
Reviews
01/25/2023

    The combination of high-quality XRCC5 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

    09/09/2019

      The manufacturer's extensive experience and expertise in the field of XRCC5 protein research make them a trusted partner.

      08/03/2019

        The manufacturer's commitment to providing excellent technical support is highly valuable.

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