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XRCC6

  • Official Full Name

    X-ray repair complementing defective repair in Chinese hamster cells 6

  • Overview

    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
  • Synonyms

    XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6; ML8; KU70; TLAA; CTC75; CTCBF; G22P1; X-ray repair cross-complementing protein 6; 5-dRP lyase Ku70; Ku autoantigen, 70kDa; DNA repair protein XRCC6; Ku autoantigen p70 subunit; 70 kDa subunit of Ku antigen; thyroid-lupus autoantigen p70; lupus Ku autoantigen protein p70; 5-deoxyribose-5-phosphate lyase Ku70; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; thyroid autoantigen 70kD (Ku antigen); ATP-dependent DNA helicase 2 subunit 1; thyroid autoantigen 70kDa (Ku antigen); ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XRCC6-2000H Recombinant Human XRCC6 protein, His-tagged Insect Cell His
Human XRCC5-149H Recombinant Human XRCC5 protein, His-tagged Insect Cell His
Human XRCC6-1548H Recombinant Human XRCC6 protein E.coli N/A
Human XRCC6-29198TH Recombinant Human XRCC6, His-tagged E.coli His
Human XRCC6-31455TH Recombinant Human XRCC6, His-tagged His
Human XRCC5 & XRCC6-543HCL Recombinant Human XRCC5 & XRCC6 cell lysate Insect Cell N/A
Human XRCC6-253HCL Recombinant Human XRCC6 293 Cell Lysate HEK293 N/A
Human XRCC6-1205H Recombinant Human XRCC6 Protein (M1-D609), His/Strep/Flag tagged E.coli His/Strep/Flag M1-D609
Human XRCC6-1204H Recombinant Human XRCC6 Protein (M1-D609), Flag tagged E.coli Flag M1-D609
Human XRCC6-5925H Recombinant Human XRCC6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human XRCC6-2371H-B Recombinant Human XRCC6 Protein Pre-coupled Magnetic Beads HEK293
Human XRCC6-5170H Recombinant Human XRCC6 protein, His-tagged E.coli His 6-222aa
Human XRCC6-484HFL Recombinant Full Length Human XRCC6 Protein, C-Flag-tagged Mammalian cells Flag
Human XRCC6-2371H Recombinant Human XRCC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse XRCC6-18640M Recombinant Mouse XRCC6 Protein Mammalian Cell His
Mouse Xrcc6-448M Recombinant Mouse Xrcc6 Protein, His-tagged E.coli His Thr319~Val538
Mouse XRCC6-10244M-B Recombinant Mouse XRCC6 Protein Pre-coupled Magnetic Beads HEK293
Mouse XRCC6-10244M Recombinant Mouse XRCC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Xrcc6-7024M Recombinant Mouse Xrcc6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Xrcc6-449R Recombinant Rat Xrcc6 Protein, His-tagged E.coli His Arg397~Arg603
Zebrafish XRCC6-10274Z Recombinant Zebrafish XRCC6 Mammalian Cell His
Chicken XRCC6-6488C Recombinant Chicken XRCC6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XRCC6 Related Research Area

XRCC6 involved in several pathways and played different roles in them. We selected most pathways XRCC6 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Non-homologous end-joiningXRCC4;XRCC5;PRKDC;FEN1;XRCC6;POLM;LIG4;DCLRE1C;DNTT

XRCC6 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC6 itself. We selected most functions XRCC6 had, and list some proteins which have the same functions with XRCC6. You can find most of the proteins on our site.

Function Related Protein
5-deoxyribose-5-phosphate lyase activityHMGA1;HMGA1-RS1;XRCC6;HMGA2
ATP bindingTLK2;MYO9B;SGK3;CFTR;P2RX3B;ADCY1;HSPA8;AK5L;CHKA
ATP-dependent DNA helicase activityERCC3;WRN;RUVBL2;BRIP1;CHD4;FBXO18;RTEL1;XRCC6;GTF2H4
DNA bindingCASZ1;ANG3;PRDM10;NCOR2;ZNF324;ZNF280D;SREBF1;MCM2;FAM60AL
damaged DNA bindingXRCC6;DCLRE1C;TDG;NEIL1;RAD1;POLK;XRCC1;RAD23AA;APTX
double-stranded DNA bindingDDX58;TDP1;DMC1;SP1;USF1;RAD51AP1;XRCC2;RAD51L1;PIN4
contributes_to double-stranded telomeric DNA bindingXRCC5;XRCC6
poly(A) RNA bindingRBM38;EBI3;EIF4E2;HMGB2;RPS24;RPL18A;RPL5B;DCD;ERI3
protein C-terminus bindingPRKAA1;MSH2;PHB2;HSPG2;HIC2;KCNK3;ZBTB16;HSPB7;PFKM
protein bindingCKB;PKMYT1;TXNDC16;CANX;EPS8L1;PRPF31;TBXAS1;CCNY;NLRP12
transcription regulatory region DNA bindingTAF7L;DHX36;TCF7L2;CBX4;MLL1;HNRNPL;Ar;IKZF1;BRD7

XRCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC6.

XRCC5; PRKDC; WRN

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