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XRN1

Official Full Name

5"-3" exoribonuclease 1
Overview

SEP1 has been reported by group of Takahashi, as a gene enhancing its expression by stimulation by a neurotrophic factor, GDNF. Though SEP1 is found in every organ, it is located at neurite of neuroblastoma cells of which differentiation is induced by GDNF, and SEP1 expression has been confirmed in many of neurons in an organism. That indicates a possibility that SEP1 relates to neural functions.
Synonyms

XRN1; 5"-3" exoribonuclease 1; SEP1; Strand-exchange protein 1 homolog; FLJ41903; DKFZp434P0721; DKFZp686B22225; DKFZp686F19113; OTTHUMP00000214507; OTTHUMP00000214577; OTTHUMP00000214578; EC 3.1.11;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Rat
Zebrafish

Source

E.coli
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	XRN1-101H	Recombinant Human XRN1, GST-tagged	Wheat Germ	GST		Inquiry
Human	XRN1-102H	Recombinant Human XRN1, His-tagged	E.coli	His		$319 / 25ug
Human	XRN1-1940HCL	Recombinant Human XRN1 cell lysate		N/A		Inquiry
Human	XRN1-552HF	Recombinant Full Length Human XRN1 Protein, GST-tagged	In Vitro Cell Free System	GST	459 amino acids	Inquiry
Rat	Xrn1-7912R	Recombinant Rat Xrn1 protein, His & T7-tagged	E.coli	His/T7	Phe1567~Glu1723 (Accession # D4ABN8)	Inquiry
Zebrafish	XRN1-11265Z	Recombinant Zebrafish XRN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
XRN1 Related Articles

XRN1 involved in several pathways and played different roles in them. We selected most pathways XRN1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome biogenesis in eukaryotes	NMD3;NVL;RPP30;WDR3;REX1;SPATA5;NOB1;RCL1;NXF2
RNA degradation	PAN3;CNOT6L;CNOT1;NUDT16;DnaK;SKIV2L;EXOSC7;PFKL;CNOT3B

XRN1 has several biochemical functions, for example, DNA binding, exonuclease activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRN1 itself. We selected most functions XRN1 had, and list some proteins which have the same functions with XRN1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZNF319;MBD1B;ING2;FOXO1A;ZNF10;ZNF577;ZSCAN18;CLSPN;HIST1H4B
exonuclease activity	WRN;EXO1;DOM3Z;FEN1;XRN1;TDP1;RAD9;AEN;EXOSC9
poly(A) RNA binding	MRPS15;GNL2;EXOSC6;FKBP4;RRP9;MRPS9;SARS2;HNRNPF;MEX3B
protein binding	SFRP5;KCTD17;SULT4A1;VAPB;IGHMBP2;FAM206A;GNA12;TMPRSS4;DHRS1

XRN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRN1.

UPF1; yp016_human; AP1G2; STAM2; LDHA; ALDOA; HNRNPA1; BAG6; CCT5; PABPC4; CHD4; flgE; napF; WAPAL; mnaA; tcaC1; VWA5B2; SPATA20; SMARCD2

Wollschlaeger, C; Trevijano-Contador, N; et al. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: Implications for virulence and mating. FUNGAL GENETICS AND BIOLOGY 73:20-28(2014).

Haralambieva, IH; Oberg, AL; et al. High-Dimensional Gene Expression Profiling Studies in High and Low Responders to Primary Smallpox Vaccination. JOURNAL OF INFECTIOUS DISEASES 206:1512-1520(2012).