ADAP1
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Official Full Name
ArfGAP with dual PH domains 1
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Overview
Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene. -
Synonyms
ADAP1; ArfGAP with dual PH domains 1; arf-GAP with dual PH domain-containing protein 1; CENTA1; Centaurin, alpha 1; GCS1L; p42IP4; Putative MAPK activating protein PM25; inositol(1,3,4,5)tetrakisphosphate receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ADAP1-0005H | Recombinant Human ADAP1 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ADAP1-5675H | Recombinant Human ADAP1 protein, His & T7-tagged | E.coli | His/T7 | Ser45~Asp356 (Accession # O75689) | |
Human | ADAP1-3615H | Recombinant Human ADAP1, His-tagged | E.Coli or Yeast | His | 374 | |
Human | ADAP1-335HCL | Recombinant Human ADAP1 cell lysate | N/A | |||
Human | ADAP1-2483H | Recombinant Human ADAP1 protein, GST-tagged | E.coli | GST | 1-374aa | |
Human | ADAP1-2576HF | Recombinant Full Length Human ADAP1 Protein, GST-tagged | In Vitro Cell Free System | GST | 374 amino acids | |
Human | ADAP1-0166H | Recombinant Human ADAP1 Protein (Ser45-Asp356), N-His-tagged | E.coli | N-His | Ser45-Asp356 | |
Human | ADAP1-1149H | Recombinant Human ADAP1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Mouse | Adap1-1534M | Recombinant Mouse Adap1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
- Involved Pathway
- Protein Function
- Interacting Protein
ADAP1 involved in several pathways and played different roles in them. We selected most pathways ADAP1 participated on our site, such as Arf6 signaling events, Class I PI3K signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arf6 signaling events | EGF;ADRB2;EFNA1;ADAP1;IPCEF1;USP6;EGFR;EPHA2;ARAP2 |
Class I PI3K signaling events | ADAP1;PLEKHA1;ARF1;ITK;BLK |
ADAP1 has several biochemical functions, for example, GTPase activator activity, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAP1 itself. We selected most functions ADAP1 had, and list some proteins which have the same functions with ADAP1. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | NIPAL1;DLC1;GIT2;GDI1;RALBP1;BCR;RAP1GDS1;ARAP3;TBC1D3B |
inositol 1,3,4,5 tetrakisphosphate binding | ADAP1;ITPR3;SYT2;ADAP2;AKR1C1 |
metal ion binding | ATP13A3;MICAL2B;RNF128A;NR1D2B;KCNIP3B;ZFYVE27;FGD6;ARHGEF28;CREB5 |
protein binding | FAM153C;KCNN4;RRAS;SIGIRR;BRD2;EFS;SERP1;TFAP2A;CD14 |
ADAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAP1.
GOLGA2; DVL3; SDCBP2; SRPK2; GADD45A; GSK3B; PSME3; q6zuh1_human; CSNK1A1
- Q&As
- Reviews
Q&As (12)
Ask a questionTo be successful, ADAP1-based therapies will need to overcome several challenges. These include the specificity of its activity and potential off-target effects, determining optimal dosing and route of administration, and ensuring the therapies are safe and effective. Additionally, regulatory approval and commercialization of such therapies may also be challenging.
ADAP1-based therapies could have several potential benefits compared to current treatments. They could target specific pathways involved in certain diseases, potentially improving treatment effectiveness while minimizing side effects. Additionally, ADAP1-based therapies may have broader applications than current treatments, potentially being effective for multiple diseases.
ADAP1 protein is being explored for its potential therapeutic applications in various fields, including cancer therapy, neurodegenerative diseases, cardiovascular diseases, and immune-related disorders. Its involvement in the regulation of cell signaling pathways and synaptic plasticity may make it a promising target for the development of therapies to treat these conditions.
ADAP1 protein has potential applications in medicine for conditions related to cell signaling, synaptic plasticity, and the immune system. It could be used to develop therapies for neurological disorders such as Alzheimer's, schizophrenia, and epilepsy. It could also be used in immunotherapy to modulate immune cell activity and improve the efficacy of cancer treatment.
Yes, ADAP1 protein is involved in the regulation of the immune system. It plays a role in the activation and differentiation of T cells, as well as the production of cytokines and chemokines involved in the immune response. Additionally, ADAP1 may be involved in the regulation of immune checkpoints, which are important modulators of immune cell activation and antigen recognition.
ADAP1 protein may have potential as a target for the development of cancer therapies. It has been shown to play a role in regulating cell proliferation and migration, and its expression is often altered in cancer cells. Additionally, ADAP1 may play a role in the regulation of tumor angiogenesis and immune evasion, making it a potential target for the development of combination therapies.
One challenge associated with the development of ADAP1-based therapies is the specificity of its activity and potential off-target effects. ADAP1 protein interacts with many signaling proteins in the cell, some of which may have overlapping functions or play a role in normal physiological processes. Thus, it is important to develop selective inhibitors or modulators of ADAP1 activity to avoid unwanted side effects. Additionally, the optimal dosing and route of administration for ADAP1-based therapies remains to be determined through further research.
There is some evidence to suggest that ADAP1 protein may have potential as a therapeutic target for the treatment of cardiovascular diseases, such as hypertension and atherosclerosis. Its involvement in the regulation of cell signaling pathways that are involved in vascular remodeling and inflammation could make it a promising target for the development of small molecule inhibitors or biologic agents. However, additional research is needed to evaluate the safety and efficacy of these therapies.
ADAP1 protein may have potential as a therapeutic agent for the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It has been shown to play a role in regulating synaptic function and plasticity, which are critical for maintaining normal cognitive function and behavior. Additionally, ADAP1 may play a role in the regulation of oxidative stress, inflammation, and cell death, which are all involved in the pathogenesis of neurodegenerative diseases.
Currently, there are no clinical trials investigating the therapeutic potential of ADAP1 protein. However, preclinical studies are ongoing to evaluate its safety and efficacy in various applications, including cancer therapy and neurodegenerative diseases. Additional research is needed to determine the potential benefits and optimal dosing regimens for ADAP1-based therapies.
ADAP1-based therapies are still in the early stages of development. There are some studies exploring the potential of ADAP1 protein as a therapeutic target, but no ADAP1-based therapies have been approved for clinical use yet. Further research is needed to determine the safety and efficacy of ADAP1-based therapies.
ADAP1 protein binds to and regulates the activity of various proteins involved in cell signaling pathways, such as the protein kinase C (PKC) family and the small GTPase RhoA. It can either activate or inhibit these proteins depending on its binding partners and cellular context, thus modulating downstream signaling pathways involved in many cellular processes, such as cell proliferation, migration, and survival.
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