ADCY1B
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ADCY1B-7644Z | Recombinant Zebrafish ADCY1B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ADCY1B involved in several pathways and played different roles in them. We selected most pathways ADCY1B participated on our site, such as Purine metabolism, Calcium signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Purine metabolism | ENTPD2;XDH;AK5;PAPSS2;URAH;NT5C1B-RDH14;PKLR;PDE10A;PDE6A |
Calcium signaling pathway | PTAFR;CALM2A;ITPR3;SLC8A3;P2RX8;PRKCBA;ADRA1D;ADRa1A;BDKRB1 |
Oocyte meiosis | RPS6KAL;ANAPC1;FBXO43;CALM1A;CPEB3;ANAPC7;PPP2CA;STAG3;CAMK2G1 |
Adrenergic signaling in cardiomyocytes | TPM1;SCN1BA;CACNG7;ATP1B3;TNNI3;CALM;ATP1B1;ADCY8;CACNA1SA |
Vascular smooth muscle contraction | PPP1CBL;PPP1CB;GNAQ;CALM;PPP1CC;PPP1R12A;PTGIR;RHOAC;MAPK3 |
Gap junction | ADRB3B;ITPR3;CX43;CSNK1DB;MAP2K1;RAF1A;TUBA3D;PRKG2;PDGFB |
GnRH signaling pathway | GNA15.1;MAP2K2;MAP2K3;PLA2G4AA;MAP2K2A;PRKCA;MMP14;ITPR3;GNRH1 |
Progesterone-mediated oocyte maturation | RPS6KA3A;MOS;MAP2K1;SPDYB;PRKACG;PIK3CA;PIK3R3;GNAI3;RAF1 |
Melanogenesis | WNT7B;HRASA;EDNRB2;WNT4;TYRP1;WNT6;PRKACB;CAMK2G;PRKCBA |
ADCY1B has several biochemical functions, for example, adenylate cyclase activity, lyase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY1B itself. We selected most functions ADCY1B had, and list some proteins which have the same functions with ADCY1B. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
adenylate cyclase activity | ADCY9;ADCY3;ADCY2B;ADCY1A;ADCY1;ADCY1B;Adcy4;ADCY6;ADCY8 |
lyase activity | ECHDC2;IRG1L;Car12;CAR15;ALDOCA;GUCY2F;MOCOS;ADCY2B;GC2 |
nucleotide binding | STK25A;UBE1Y1;RAD51L3;TMEM63A;ZCRB1;ATP2B3A;EWSR1B;LARP7;DPYDB |
phosphorus-oxygen lyase activity | CD38;ADCY1A;ADCY2B;GC3;GUCY2E;GC2;ADCY1B;NPR1A;GUCY2F |
ADCY1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY1B.
- Q&As
- Reviews
Q&As (12)
Ask a questionCurrently, there are no FDA-approved drugs that directly target ADCY1B. However, there are several drugs that indirectly affect cAMP signaling, including beta-blockers, which inhibit the activity of beta-adrenergic receptors that activate ADCY1B.
The potential risks and side effects of ADCY1B-targeted therapies depend on the specific compound and its mechanism of action. Some compounds may increase cAMP signaling and lead to side effects such as increased heart rate, anxiety, and tremors. Others may decrease cAMP signaling and lead to side effects such as fatigue, depression, and decreased immune function. Additionally, modulation of ADCY1B may impact other physiological processes, which could lead to unexpected side effects.
Knowledge of ADCY1B expression and activity in different populations and disease states can be used to develop personalized medicine approaches that target this enzyme. For example, patients with certain types of cancer or metabolic disorders may benefit from ADCY1B-targeted therapies, while others may be at increased risk for side effects. Additionally, genetic variations that impact ADCY1B expression or activity may be used to identify patients who are more likely to respond to certain therapies.
ADCY1B has been implicated in the pathogenesis of various diseases, including type 2 diabetes, Parkinson's disease, and cancer. Targeting ADCY1B may be a potential strategy for treating these conditions, as well as other diseases that involve dysregulation of cAMP signaling.
The potential therapeutic applications of targeting ADCY1B include treatment of metabolic disorders such as obesity and type 2 diabetes, as well as cancer and neurological disorders. By modulating cAMP signaling, ADCY1B-targeted therapies may regulate glucose and lipid metabolism, inhibit tumor growth and metastasis, and improve neuronal signaling.
One of the major challenges of developing ADCY1B-targeted therapies is achieving specificity and avoiding off-target effects. ADCY1B is part of a complex signaling pathway, and modulation of its activity may impact other physiological processes. Additionally, different compounds may have different effects on cAMP signaling, and the optimal dose and mode of administration may vary depending on the disease being targeted.
ADCY1B can be targeted for medical applications through the development of compounds that modulate its activity or expression. These compounds can potentially increase or decrease cAMP signaling, depending on the specific application.
ADCY1B-targeted therapies are typically developed through a process that involves identifying potential compounds, testing their effects on ADCY1B activity and cAMP signaling in vitro and in animal models, and conducting clinical trials to evaluate their safety and efficacy in humans.
ADCY1B can be targeted therapeutically using small molecule inhibitors or activators that modulate its enzymatic activity. Additionally, gene therapy approaches that modulate the expression or function of ADCY1B may be used. These therapies can be administered orally, intravenously, or through injections, depending on the compound and the disease being targeted.
There are several natural compounds that have been shown to modulate ADCY1B activity, including forskolin, an extract from the Coleus forskohlii plant, and caffeine, a stimulant found in coffee and other beverages. These compounds indirectly increase cAMP signaling by activating or inhibiting other components of the signaling pathway.
One potential limitation of targeting ADCY1B is the potential for side effects. By modulating cAMP signaling, ADCY1B-targeted therapies may impact a variety of physiological processes, and off-target effects may occur. Additionally, the effectiveness of these therapies may depend on the specific disease being targeted and the genetic profile of the patient, which may limit their applicability.
To our knowledge, there are no ADCY1B-targeted therapies currently in clinical trials. However, several small molecule inhibitors of ADCY1B have been developed and tested in preclinical models of cancer and metabolic disorders, and some have shown promising results.
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