ANKK1
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Official Full Name
ankyrin repeat and kinase domain containing 1
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Overview
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. -
Synonyms
ANKK1; ankyrin repeat and kinase domain containing 1; ankyrin repeat and protein kinase domain-containing protein 1; X kinase; sgK288; X-kinase; sugen kinase 288; protein kinase PKK2; PKK2;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANKK1-566H | Recombinant Human ANKK1 protein, GST-tagged | Wheat Germ | GST | ||
Human | ANKK1-1437HF | Recombinant Full Length Human ANKK1 Protein, GST-tagged | In Vitro Cell Free System | GST | 765 amino acids | |
Zebrafish | ANKK1-7122Z | Recombinant Zebrafish ANKK1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ANKK1 involved in several pathways and played different roles in them. We selected most pathways ANKK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANKK1 has several biochemical functions, for example, ATP binding, kinase activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKK1 itself. We selected most functions ANKK1 had, and list some proteins which have the same functions with ANKK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | NAT1;DCLK1A;ATP2A3;TOP2A;DGKG;ATP9B;UBE2D1;MSH3;KATNAL2 |
kinase activity | PLAUA;PKDCCA;ADKB;PRKAR2AA;CAMK1DA;NME2A;GM7168;MAP2K4A;BAIAP2L1A |
protein kinase activity | PTK2BB;PRKCHA;MAP2K4B;EPHB3A;GM711;GRK1B;ABL2;MAP3K4;HIPK3A |
transferase activity | PDSS1;PI4KAA;BMPR1BA;RPS6KA3A;HIPK2;SULT3ST3;REV3L;MAT2AA;AGPHD1 |
ANKK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKK1.
- Q&As
- Reviews
Q&As (18)
Ask a questionCurrently, there are no specific targeted therapies available for ANKK1 protein. However, understanding its functions and associations may provide insights into developing potential treatment approaches in the future.
ANKK1 protein is still being studied in the context of disease associations, and its use as a diagnostic or prognostic marker is unclear at this time. Some research suggests that variations in the ANKK1 gene, such as the Taq1A polymorphism, may be associated with an increased risk for certain psychiatric disorders, including schizophrenia and addiction. However, further research is needed to determine the clinical utility of ANKK1 protein as a diagnostic or prognostic marker.
Some studies have suggested that variations in the ANKK1 gene, particularly the Taq1A polymorphism, may influence an individual's response to medications that affect dopamine signaling. For example, it has been suggested that individuals with the Taq1A A1 allele may have a different response to antipsychotic medications used to treat schizophrenia. However, the evidence is still limited and more research is needed to fully understand the impact of ANKK1 variations on medication response.
ANKK1 protein is composed of several domains, including ankyrin repeat domains and a protein kinase domain. These domains are involved in protein-protein interactions and enzymatic activities.
The regulation of ANKK1 protein is still being investigated. However, it is thought that its expression and activity can be influenced by various factors, including genetic and epigenetic mechanisms, as well as environmental factors.
Yes, animal models have been used to study the role of ANKK1 protein in various biological processes. Mice models with genetic modifications to the ANKK1 gene have been generated to explore its function in dopamine signaling and addiction-related behaviors. Additionally, cell culture systems and other experimental techniques are employed to investigate ANKK1 expression, localization, and interactions with other molecules. These models provide valuable insights into the role of ANKK1 in cellular physiology and disease mechanisms.
ANKK1 protein is known to be expressed in various tissues and organs, including the brain, liver, kidney, and bone. In the brain, ANKK1 is predominantly found in regions associated with dopamine signaling, such as the striatum. However, the exact tissue-specific expression pattern and its functional implications in different organs are still being investigated.
ANKK1 protein continues to be an area of active research. Future studies are likely to focus on further elucidating its role in dopamine receptor signaling and addiction, as well as its potential involvement in other neurological and psychiatric disorders. Additionally, investigations into the regulation and functional implications of ANKK1, as well as its potential as a therapeutic target, are also emerging areas of interest.
ANKK1 protein is known to interact with dopamine receptors, particularly the D2-like receptors (DRD2, DRD3, DRD4). This interaction suggests a role in modulating dopamine receptor signaling and may contribute to its involvement in reward systems and addiction.
Currently, there are no known specific inhibitors or activators of ANKK1 protein. The functional implications of ANKK1 and its potential as a therapeutic target are still being explored. Some studies have investigated compounds that modulate dopamine receptor signaling, which may indirectly affect ANKK1 activity. However, more research is needed to fully understand the regulation and manipulation of ANKK1 protein.
The regulation of ANKK1 protein within cells is not fully understood. However, it is known that ANKK1 expression can be influenced by genetic factors, such as variations in the ANKK1 gene. Other factors, such as hormonal regulation, epigenetic modifications, and environmental cues, may also play a role in regulating ANKK1 protein levels and activity. Further research is needed to unravel the complex regulatory mechanisms that govern ANKK1 expression and function.
The relationship between ANKK1 and drug targets is an area of ongoing research. Some studies suggest that ANKK1 may influence responses to certain medications, particularly those targeting dopamine receptors or substances affecting reward pathways. However, more research is needed to fully understand the extent of these implications.
Yes, ANKK1 protein is also known by other names, including "ankyrin repeat and protein kinase domain-containing protein 1" and "nyctalopin-interacting protein 2".
Although the therapeutic implications of ANKK1 protein research are not yet well established, understanding the role of ANKK1 in dopamine receptor signaling and its association with certain psychiatric disorders could potentially lead to the development of novel therapeutic strategies. Targeting ANKK1 or its downstream signaling pathways may offer new avenues for the treatment of conditions such as addiction, schizophrenia, and other dopamine-related disorders. However, more research is needed to fully uncover the therapeutic potential of ANKK1 protein.
ANKK1 protein is believed to be involved in various cellular processes and signaling pathways. It has been implicated in dopamine receptor signaling and is thought to modulate the activity of D2-like dopamine receptors. Additionally, ANKK1 may play a role in neuronal development and synaptic plasticity, although the exact mechanisms are not fully understood.
Some studies have reported associations between ANKK1 gene variants and an increased risk for substance use disorders, addictive behaviors, and neuropsychiatric disorders. However, further research is needed to fully understand these associations.
Yes, there are known genetic variants and mutations of the ANKK1 gene. One well-known variant is the Taq1A polymorphism, which has been associated with various neuropsychiatric disorders and substance use disorders.
ANKK1 itself is not currently recognized as a causative gene for any specific genetic disorders. However, variations in the ANKK1 gene, such as the Taq1A polymorphism, have been associated with an increased susceptibility to substance use disorders and some psychiatric conditions. It's important to note that the association between ANKK1 and these disorders is complex and influenced by various genetic and environmental factors.
Customer Reviews (4)
Write a reviewIts high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
Scientists who have employed ANKK1 protein in their experiments have praised its outstanding performance and reliability.
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