ANO4
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Official Full Name
anoctamin 4
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Synonyms
ANO4;anoctamin 4;23837;ENSG00000151572;TMEM16D;12q23.1;FLJ34221, FLJ34272, FLJ35277, MGC130026;anoctamin-4;anoctamin-4;transmembrane protein 16D;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ANO4-970H | Recombinant Human ANO4 | Mammalian Cell | His | ||
Human | ANO4-2477H | Recombinant Human ANO4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ANO4-2477H-B | Recombinant Human ANO4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bovine | ANO4-3501B | Recombinant Bovine ANO4, His-tagged | E.Coli or Yeast | His | 920 |
- Involved Pathway
- Protein Function
- Interacting Protein
ANO4 involved in several pathways and played different roles in them. We selected most pathways ANO4 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ion channel transport | OSTM1;ATP13A5;TPCN1;TRPC4;ATP1A1A.2;TRPM1A;TTYH3;PDZD11;TRPC4B |
Stimuli-sensing channels | ANO5;WNK1;CLCNKA;CLCN7;CLCN5;TRPM4A;UNC79;BSND;TPCN1 |
Transmembrane transport of small molecules | TTYH2;SLC30A2;DMTN;ABCA7;SLC41A1;SLC5A6A;SLC22A6;SLC15A4;BSND |
ANO4 has several biochemical functions, for example, intracellular calcium activated chloride channel activity, phospholipid scramblase activity, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO4 itself. We selected most functions ANO4 had, and list some proteins which have the same functions with ANO4. You can find most of the proteins on our site.
Function | Related Protein |
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intracellular calcium activated chloride channel activity | TTYH3;ANO2;CLCA4;ANO7;ANO8;CLCA2;ANO4;ANO6;NMUR2 |
phospholipid scramblase activity | Ano3;PLSCR3;PLSCR4;PLSCR1;PLSCR2;ANO9;PLSCR3A;ANO7;PLSCR3B |
protein dimerization activity | HIF3A;MEF2AA;FBXW11;HER13;ATOH1;PPP3CB;TFAP2C;GRIN2A;CREB3 |
ANO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO4.
- Q&As
- Reviews
Q&As (22)
Ask a questionThere is limited evidence suggesting a possible association between ANO4 protein and cancer. Studies have shown altered ANO4 expression in certain cancer types, but more research is necessary to determine its precise role in tumorigenesis.
Currently, there are no specific inhibitors or activators of ANO4 protein that have been widely characterized. However, ongoing research is focusing on identifying small molecules or compounds that can modulate its activity.
It is still not fully understood whether alterations in ANO4 protein expression or function directly contribute to disease development. However, a better understanding of its role in various tissues may provide insights into potential disease mechanisms and therapeutic strategies.
Recent studies have indicated that ANO4 protein may be involved in pain processing. It has been found to modulate nociceptor excitability and contribute to inflammatory pain hypersensitivity.
Currently, there are no specific inhibitors or activators of ANO4 protein. However, ongoing research may identify substances or compounds that can modulate its activity.
Yes, genetic disorders associated with ANO4 protein have been identified. For example, mutations in ANO4 have been linked to autosomal recessive spinocerebellar ataxia.
Yes, ANO4 protein can interact with various proteins to form functional complexes. For example, it has been found to interact with the cystic fibrosis transmembrane conductance regulator (CFTR), another chloride channel, in airway epithelial cells.
Yes, ANO4 mutations can be inherited. In the case of gnathodiaphyseal dysplasia, it is inherited in an autosomal dominant manner, which means a single copy of the mutated gene from one parent is sufficient to cause the condition.
Mutations in the ANO4 gene have been identified in individuals with hereditary gnathodiaphyseal dysplasia, which is a rare skeletal disorder characterized by bone abnormalities in the jaw and other skeletal structures.
Yes, animal models, such as mice with ANO4 gene knockout or overexpression, have been generated to investigate the physiological roles of ANO4 protein. These models can provide valuable insights into its functions and associated diseases.
As of now, there are no specific drugs targeting ANO4 protein in clinical use or advanced stages of development. However, with increasing knowledge about its structure and function, it is possible that novel therapeutic interventions may be explored in the future.
While the exact physiological roles of ANO4 protein are still being investigated, recent studies suggest its involvement in processes such as insulin secretion in pancreatic beta cells and regulation of smooth muscle contraction.
Yes, genetic mutations in the ANO4 gene have been identified in individuals with gnathodiaphyseal dysplasia. However, the full spectrum of mutations and their effects on protein function and disease development is not yet fully characterized.
The regulation of ANO4 protein expression in different tissues is not well understood. Further research is needed to determine the factors and mechanisms that control its expression levels.
ANO4 protein has been implicated in sensory perception, particularly in taste perception. It is expressed in taste bud cells and appears to play a role in the detection of sour taste stimuli.
Yes, several disease-associated mutations have been identified in the ANO4 gene. For example, mutations in ANO4 have been linked to hereditary motor and sensory neuropathy and gnathodiaphyseal dysplasia.
The potential use of ANO4 protein as a biomarker for specific diseases is still being explored. However, some studies have suggested its potential as a biomarker for certain cancers, such as lung and pancreatic cancer.
There is evidence to suggest that changes in ANO4 protein expression or function can affect neuronal activity. ANO4 has been shown to regulate neuronal excitability and synaptic transmission in both the central and peripheral nervous systems.
ANO4 protein belongs to the Anoctamin family, which comprises ten closely related proteins. It shares structural similarities with other members of the family, including conserved transmembrane domains and intracellular loops.
ANO4 protein is evolutionarily conserved and found in various vertebrate species. Its presence indicates that it likely has important functions across different organisms.
ANO4 protein is primarily localized to the plasma membrane, where it functions as a chloride channel. However, it may also have other subcellular localizations depending on the context and cell type. Further research is needed to determine its precise localization in different cellular compartments.
Yes, ANO4 protein can be regulated by various signaling pathways. For example, activation of protein kinase A (PKA) has been shown to enhance ANO4 channel activity.
Customer Reviews (4)
Write a reviewANO4 protein demonstrates great utility in protein electron microscopy structure analysis.
The high-quality ANO4 protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.
The use of ANO4 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.
In WB experiments, ANO4 protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.
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