APOA1
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Official Full Name
apolipoprotein A-I
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Overview
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008] -
Synonyms
APOA1; apolipoprotein A-I; apo-AI; Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Chimpanzee
- Cynomolgus Monkey
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Dog
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human cells
- Human plasma
- Human Plasma
- Human Plasma HDL
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Fc
- Flag
- GST
- hFc
- His (Fc)
- Avi
- His|GST
- B2M
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- APOA1 Related Articles
- APOA1 Related Research Area
APOA1 involved in several pathways and played different roles in them. We selected most pathways APOA1 participated on our site, such as PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PPAR signaling pathway | FABP4;GK;AQP7;Scd1;ACOX2;RXRGA;LPL;FABP2;MMP1 |
Fat digestion and absorption | PLA2G2A;PPAP2A;SCARB1;PNLIP;PLA2G10;MOGAT2;APOA1;PLA2G12B;APOA4 |
Vitamin digestion and absorption | SLC52A3;MMACHC;FOLH1;APOA1;SCARB1;ABCC1;SLC19A2;GIF;LRAT |
African trypanosomiasis | IL18;THOP1;Fasl;PRKCA;IL1B2;APOA1;PLCB4;GNAQ;HBB-B2 |
APOA1 has several biochemical functions, for example, apolipoprotein A-I receptor binding, apolipoprotein receptor binding, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1 itself. We selected most functions APOA1 had, and list some proteins which have the same functions with APOA1. You can find most of the proteins on our site.
Function | Related Protein |
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apolipoprotein A-I receptor binding | CDC42;NR1H2;APOA1 |
apolipoprotein receptor binding | APOA1;PCSK9;APOA2 |
beta-amyloid binding | BACE2;APBB3;ARMCX5-GPRASP2;ITM2C;ACHE;LDLRAP1;TM2D1;GPRASP2;HSD17B10 |
chemorepellent activity | SEMA6DL;SEMA5A;SEMA3AA;SEMA3A;EPHA7;UBE4A;FLRT2;SEMA6B;SEMA3FA |
cholesterol binding | ERLIN1;APOA4;ANXA6;OSBPL1A;SOAT1;ABCA1;PROM2;SCP2;APOA4B.1 |
contributes_to cholesterol transporter activity | ABCG8;APOA2;APOA1;SFRP5;ABCG5 |
cholesterol transporter activity | APOA5;ABCA4;APOA1A;APOEB;ABCA13;STAR;ABCA1;APOA4;APOA4B.2 |
enzyme binding | ARRB2;GRIN1;UBE4B;TRP53;H2AFX;NKX2-1;DNMT3L;PEX7;TMBIM6 |
high-density lipoprotein particle binding | APOA1;APOA1A;APOL2;APOA2;GPIHBP1 |
high-density lipoprotein particle receptor binding | APOA2;APOC3;APOA1 |
identical protein binding | P2RX6;ZNHIT6;KCNJ2;AHI1;KLHL7;ATG101;CHAF1A;TNPO3;PTS |
lipase inhibitor activity | APOA2;APOC2;APOC3;APOA1;FAF2;APOC1 |
phosphatidylcholine binding | CHMP2A;APOC1;APOA5;GPR119;ESYT2;CHMP3;NF1;GPR12;RPE65 |
phosphatidylcholine-sterol O-acyltransferase activator activity | APOA1A;APOA4B.1;APOA4;APOEB;APOA4A;APOC1;APOA4B.2;APOA5;APOEA |
phospholipid binding | APOH;MYOF;APOB;PACSIN1;SEC14L2;ESYT1;GLTPD1;ABCA1;PREX1 |
phospholipid transporter activity | ABCG1;MFSD2AA;MFSD2A;MTTP;OSBPL5;CETP;APOA1;ABCA7;ABCA4 |
protein binding | CNIH4;ZFAND5;LMLN;STX12;SEMA7A;CD99L2;DNAJC11;SDCBP;KIF2A |
APOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1.
APP; HP
- Q&As
- Reviews
Q&As (17)
Ask a questionMeasurement of APOA1 protein levels is not commonly used as a standalone diagnostic marker for cardiovascular diseases. However, it is often measured as part of lipid profiles to assess the risk of cardiovascular events.
While rare, some genetic mutations can lead to elevated APOA1 protein levels. However, the impact of increased APOA1 levels on overall health and disease risk is not yet fully understood.
APOA1 protein levels are commonly measured along with other lipid markers during cardiovascular risk assessments. However, a single measurement of APOA1 protein levels is not sufficient for diagnosis and is usually interpreted in conjunction with other clinical factors.
Yes, mutations in the APOA1 gene can cause rare genetic disorders such as familial HDL deficiency or Tangier disease. These conditions are characterized by extremely low levels of HDL cholesterol and may lead to premature cardiovascular diseases.
Yes, lifestyle factors can impact APOA1 protein levels and HDL cholesterol levels. Regular exercise, a healthy diet rich in fruits, vegetables, whole grains, and unsaturated fats, can help raise HDL cholesterol levels, potentially increasing APOA1 protein production. Conversely, an unhealthy lifestyle, such as a diet high in saturated fats and sedentary behavior, can lower HDL cholesterol levels.
APOA1 binds to cholesterol and phospholipids in peripheral tissues, such as macrophages. It forms nascent HDL particles, which then accept additional cholesterol from cells. These cholesterol-loaded HDL particles are subsequently transferred to the liver for excretion or recycling.
Yes, variations in APOA1 protein levels and functions have been associated with other health conditions. Some studies suggest a potential link between APOA1 protein deficiency and metabolic disorders, including diabetes and obesity.
The APOA1 protein interacts with several enzymes, receptors, and other proteins involved in lipid metabolism and inflammation. Some examples include interactions with lecithin-cholesterol acyltransferase (LCAT) for cholesterol esterification and with scavenger receptor class B type 1 (SR-B1) for cholesterol uptake in the liver. These interactions play crucial roles in the function and regulation of HDL metabolism.
Recent research suggests that the APOA1 protein may have neuroprotective effects in the brain. It has been associated with decreased risk of neurodegenerative diseases, such as Alzheimer's disease, and may play a role in synaptic function and repair.
Yes, APOA1 is a major component of HDL particles. It plays a crucial role in the formation and maturation of HDL, as well as in the reverse cholesterol transport pathway. Therefore, alterations in APOA1 protein levels or functionality can impact HDL cholesterol levels.
The APOA1 protein possesses anti-inflammatory properties and can modulate immune responses. It is known to inhibit the production of inflammatory cytokines and adhesion molecules, which play a role in the development of atherosclerosis and other inflammatory conditions.
Yes, lifestyle choices can influence APOA1 protein levels. Regular exercise, a healthy diet low in saturated fats, and moderate alcohol consumption have been shown to increase levels of APOA1 protein and improve HDL cholesterol levels.
Researchers are investigating various approaches to boost APOA1 protein levels, such as using synthetic versions of APOA1 or developing drugs that mimic its functions. These strategies aim to enhance reverse cholesterol transport and potentially reduce the risk of cardiovascular diseases.
Various strategies are being explored, including the use of APOA1 mimetic peptides and gene therapy approaches to increase APOA1 protein levels or enhance its functionality. However, these interventions are still in the preclinical or early clinical trial stages.
Dysfunctional APOA1 protein can contribute to the development of familial hypoalphalipoproteinemia, a condition characterized by low levels of high-density lipoprotein (HDL) cholesterol. Low HDL levels are associated with an increased risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease.
APOA1 protein deficiency can lead to impaired reverse cholesterol transport, resulting in increased levels of low-density lipoprotein (LDL) or "bad cholesterol" and decreased levels of HDL. This imbalance is associated with a higher risk of cardiovascular diseases, including atherosclerosis and heart disease.
The liver is the primary site of APOA1 protein synthesis, but it can also be produced by other tissues, such as the intestine. Intestinal APOA1 contributes to the local production of HDL and can influence systemic lipid metabolism.
Customer Reviews (4)
Write a reviewI am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.
Its purity and reliability have provided consistent and reliable results in my research.
The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the APOA1 protein.
The APOA1 protein is of exceptional quality, making it a perfect fit for my experimental needs.
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