ARCN1A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ARCN1A-11505Z | Recombinant Zebrafish ARCN1A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARCN1A involved in several pathways and played different roles in them. We selected most pathways ARCN1A participated on our site, such as COPI Mediated Transport, Golgi to ER Retrograde Transport, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARCN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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COPI Mediated Transport | TERFA;COPG;ARCN1B;COPZ1;COPE;ARCN1;ARCN1A;COPB1;COPB2 |
Golgi to ER Retrograde Transport | COPB1;TERFA;ARCN1A;COPG;ARCN1;ARCN1B;COPB2;COPE;COPZ1 |
Membrane Trafficking | PICALM;SEC22C;AP4B1;TRAPPC6BL;ARCN1;SNX9;DTNBP1B;DAB2;TRAPPC10 |
Vesicle-mediated transport | PICALMB;FTH1A;SCGB3A2;CD163;AP1S3A;ARCN1;NAPB;TRAPPC6BL;MYO6A |
ARCN1A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ARCN1A itself. We selected most functions ARCN1A had, and list some proteins which have the same functions with ARCN1A. You can find most of the proteins on our site.
Function | Related Protein |
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ARCN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARCN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARCN1A.
- Q&As
- Reviews
Q&As (26)
Ask a questionThere is currently no information available regarding the regulation of ARCN1A by microRNAs. MicroRNAs are small RNA molecules that can target messenger RNA (mRNA) for degradation or translational repression. It is possible that microRNAs may regulate ARCN1A expression, but further studies are needed to explore this potential regulatory mechanism.
Currently, there is limited information about post-translational modifications of ARCN1A. However, it is possible that ARCN1A may undergo modifications such as phosphorylation, ubiquitination, or acetylation, which can impact its function and localization within cells.
ARCN1A interacts with various proteins to form the COP-I complex, including other subunits of the complex such as COPA and COPB1. Additionally, ARCN1A interacts with SNARE proteins and tethering factors involved in vesicle trafficking and fusion processes. These interactions are crucial for the proper functioning of the COP-I complex in intracellular transport.
ARCN1A is primarily known for its role in vesicle trafficking, particularly in mediating the assembly of the COP-I complex. However, it is possible that ARCN1A may have additional functions that have not yet been fully characterized. Further research is needed to explore any potential alternative roles of ARCN1A.
Currently, there are no known genetic disorders specifically linked to mutations in the ARCN1A gene. However, considering the critical role of ARCN1A in vesicle trafficking, it is conceivable that disruptions in its function could potentially contribute to cellular dysfunction or disease conditions.
ARCN1A interacts with other subunits of the adaptin/COP-I complex, as well as with various proteins involved in vesicle trafficking and intracellular transport, such as SNAREs, tethering factors, and regulatory enzymes.
As of now, there is limited information on the potential consequences of ARCN1A mutations or dysregulation. However, since ARCN1A is involved in vesicle trafficking, it is reasonable to hypothesize that disruptions in its function could impact intracellular transport and potentially lead to cellular defects or disease conditions.
ARCN1A is primarily localized in the cytoplasm, specifically associated with the Golgi apparatus and the endoplasmic reticulum. Its presence in COPI-coated vesicles allows it to be involved in vesicle transport between these compartments.
The specific role of ARCN1A in cell division or mitosis is not well-studied. However, as vesicle trafficking is essential for various cellular processes, it is possible that ARCN1A may also contribute to proper cell division by ensuring the accurate transportation of proteins and lipids during mitotic events.
There are currently no known drugs or compounds specifically targeting ARCN1A. However, compounds that target other components of the COP-I complex, such as Arl1-GTPase inhibitors, have been investigated for their potential therapeutic applications. Additionally, modulating the activity of upstream or downstream molecules involved in vesicle trafficking pathways may indirectly affect ARCN1A function. Further studies are required to identify specific drugs or compounds that interact with ARCN1A.
At present, there is no direct evidence implicating ARCN1A in neurodegenerative diseases. However, since proper vesicle trafficking is essential for neuronal function, future research may explore the potential involvement of ARCN1A in neurodegenerative disorders.
Limited research has been conducted on the role of ARCN1A in cancer. However, one study suggested that ARCN1A may play a role in promoting metastasis in breast cancer by modulating the activity of certain signaling pathways. Further investigation is needed to fully understand the potential implications of ARCN1A in cancer development and progression.
ARCN1A helps in the formation and maintenance of COPI-coated vesicles, which are responsible for protein and lipid sorting, maintenance of organelle integrity, and retrograde transport within the Golgi apparatus and between the Golgi and endoplasmic reticulum (ER).
ARCN1A primarily interacts with proteins involved in vesicle trafficking and intracellular transport, such as SNAREs and tethering factors. It is not known to directly interact with membrane receptors or signaling molecules, but its function in mediating vesicle transport indirectly impacts signaling cascades.
Yes, ARCN1A protein is highly conserved across different species, indicating its importance in cellular function. The amino acid sequences of ARCN1A in various organisms, from humans to model organisms like mice and yeast, are highly similar, suggesting its essential role in cellular processes.
ARCN1A has two known isoforms: ARCN1A isoform 1 and ARCN1A isoform 2. Isoform 2 has a shorter sequence due to alternative splicing of the ARCN1A gene.
The regulation of ARCN1A expression is not extensively studied, but it is possible that specific transcription factors or signaling pathways may play a role in its expression. Further research is needed to fully understand the regulatory mechanisms of ARCN1A.
At the moment, there are no known disease associations or mutations specifically linked to the ARCN1A gene. However, further research is needed to explore potential associations with various disorders.
There is limited information available on ARCN1A mutations or genetic variations in diseases. However, alterations in other components of the COP-I complex have been associated with certain diseases. For example, mutations in COPA have been linked to autoimmune and interstitial lung diseases. Further research is needed to determine if ARCN1A mutations or genetic variations contribute to disease development or progression.
ARCN1A is expressed in many different cell types and tissues. However, the expression levels of ARCN1A may vary depending on the specific cell type and its unique vesicle trafficking requirements.
There is currently limited information available on targeting ARCN1A for therapeutic intervention. However, components of the COP-I complex have been explored as potential targets for cancer therapy. Inhibiting the function of the COP-I complex could disrupt intracellular trafficking and potentially affect cancer cell survival. Further research is needed to determine the feasibility and effectiveness of targeting ARCN1A or the COP-I complex for therapeutic purposes.
Currently, there are no known alternative splicing variants or isoforms reported for the ARCN1A gene. However, alternative isoforms could potentially exist and require further investigation.
ARCN1A itself is not directly involved in protein quality control or degradation pathways. However, its function in the vesicle trafficking machinery indirectly contributes to the maintenance of protein homeostasis by facilitating the transport and sorting of proteins to their appropriate subcellular compartments, including lysosomes for degradation.
As of now, there are no specific drugs or therapeutic interventions targeting ARCN1A. However, understanding the function and regulation of ARCN1A may provide valuable insights for the development of future treatments targeting intracellular vesicle trafficking.
There is limited information available on the association between changes in ARCN1A expression levels and disease. However, dysregulation of vesicle trafficking processes has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Further research is needed to determine if alterations in ARCN1A expression contribute to disease pathogenesis or progression.
ARCN1A is highly conserved across species, including mammals, birds, reptiles, amphibians, and fish. This conservation suggests its importance in cellular processes across different organisms.
Customer Reviews (8)
Write a reviewThe manufacturer can provide researchers with high-quality ARCN1A protein, ensuring it is properly purified, characterized, and quality-controlled.
Its performance in protein electron microscopy greatly contributes to the advancement of my research in deciphering protein function and interactions.
They can also address any questions or concerns regarding the ARCN1A protein, thereby facilitating smooth and efficient research execution.
manufacturers may offer customization options, allowing researchers to tailor the ARCN1A protein to their specific needs.
This collaboration may extend beyond the purchase of the ARCN1A protein, potentially leading to additional support, joint research projects, or access to expertise in the field.
With the ARCN1A Protein, I have been able to obtain clear and precise images, enabling detailed analysis and interpretation of complex protein structures.
he ARCN1A Protein's robust reactivity with antibodies facilitates efficient and specific protein detection, enhancing the overall sensitivity of my WB analyses.
The reliability and reproducibility of the ARCN1A Protein's performance make it a go-to option for WB experiments.
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