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MARCH6

Official Full Name

membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Synonyms

MARCH6;membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase;30550;ENSG00000145495;TEB4;DOA10;RNF176;MARCH-VI;5p15.2;KIAA0597, DKFZp586L081;E3 ubiquitin-protein ligase MARCH6;E3 ubiquitin-protein ligase MARCH6;doa10 homolog;RING finger protein 176;membrane-associated RING-CH protein VI;membrane-associated RING finger protein 6;membrane-associated RING-CH finger protein 6;EC 6.3.2.-;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	MARCH6-9559M	Recombinant Mouse MARCH6 Protein	Mammalian Cell	His	Inquiry
Mouse	MARCH6-5367M-B	Recombinant Mouse MARCH6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	MARCH6-5367M	Recombinant Mouse MARCH6 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Zebrafish	MARCH6-8444Z	Recombinant Zebrafish MARCH6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MARCH6 involved in several pathways and played different roles in them. We selected most pathways MARCH6 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein processing in endoplasmic reticulum	SEC62;UBE2G1A;ATF4;HSP90B1;HSPA8;DNAJC5AA;MAPK8;HSC70;SEC23B

MARCH6 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH6 itself. We selected most functions MARCH6 had, and list some proteins which have the same functions with MARCH6. You can find most of the proteins on our site.

Function	Related Protein
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	RNF187;UBE2IB;UBE2IA;LTN1;RNF149;NEURL3;TRIM71;NEURL1B;RNF144AB
coenzyme F420-0 gamma-glutamyl ligase activity	RFWD2;SHRPRBCK1R;MGRN1A;RNF144AA;MARCH6;MARCH4;SIAH2L;G2E3;TRIM71
coenzyme F420-2 alpha-glutamyl ligase activity	TRIM71;TRIM41;TRIM50;RNF169;HERC2;RNF180;LTN1;MARCH5L;NEURL1B
enzyme binding	HSPA2;LAMP1;SUPT5H;UBE2I;MAPK8;PHB;BCR;A2M;HSPA5
ligase activity	UBE3A;RAD18;C12orf51;TRIM22;LIPT2;CCNB1IP1;NAPRT1;RBBP6;RNF212
metal ion binding	USP4;ZIM3;MMP14B;SIAH2L;ADH8B;NKD2B;ATP1A1A.4;ITGAL;CBFA2T2
protein-glutamic acid ligase activity	RNF180;RNF144AB;UBE2IB;RAG1;RNF144AA;NEURL1B;DTX1;ITCHA;SHRPRBCK1R
protein-glycine ligase activity	MARCH4;TRIM50;NEURL3;ARIH1L;UBE2IB;HECW2;RAG1;UBR1;MARCH9
protein-glycine ligase activity, elongating	SIAH1A;G2E3;ITCHA;MUL1A;TRIM71;TRIM41;UBR1;ZNRF3;MARCH9
protein-glycine ligase activity, initiating	ITCHA;RNF144AB;NEURL1B;TMEM129;TRIM41;LTN1;TRIM50;MARCH11;MGRN1A
ribosomal S6-glutamic acid ligase activity	HECW2;HERC2;RNF169;LTN1;G2E3;NEURL1B;TMEM129;SIAH1A;TRIM71
tubulin-glutamic acid ligase activity	NEURL3;UBE2IA;MARCH6;RNF169;MARCH4;SHRPRBCK1R;MARCH9;UBE2IB;HECW2
tubulin-glycine ligase activity	ZNRF2B;TRIM41;RAG1;LTN1;RNF169;UBE2IB;RNF180;MARCH4;RNF144AA
ubiquitin conjugating enzyme binding	FOXL2;DCUN1D4;PPARA;SIAH2;RNF144AB;RNF144B;TRIM72;TCHP;TRAF6
ubiquitin-protein transferase activity	TRIM62;CBLL1;ANKIB1;PAX6;CBL;MARCH6;AMFR;MUL1B;FBXW11
ubiquitin-specific protease binding	VCP;MARCH6;SELS;SYVN1;DERL1;BAG6;SART3;PARK2;AMFR
zinc ion binding	ZDHHC17;TRAF3;GATAD2A;RYBPB;LNX1;TRHDE;LHX2;NR1D2B;ADAMDEC1

MARCH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH6.

Research Area

Nakamura, N; Harada, K; et al. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6. EXPERIMENTAL CELL RESEARCH 328:207-216(2014).

Egri, P; Gereben, B; et al. Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation. JOURNAL OF MOLECULAR ENDOCRINOLOGY 53:217-226(2014).