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Recombinant Mouse Kitl protein, His-tagged, Biotinylated.

Cat.No. : Kitl-577M
Product Overview : Recombinant Mouse Kitl(Lys 26 - Ala 189) fused with His tag at C-terminal was expressed in HEK293, Biotinylated.
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  • Gene Information
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Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Lys 26
Form : Lyophilized from 0.22µm filtered solution in PBS (pH 7.4) with Trehalose as protectant.
Molecular Mass : Has a calculated MW of 19.1 kDa. The protein migrates as 19-30 kDa on a SDS-PAGE gel under reducing (R) condition due to different glycosylation.
Protein length : Lys 26 - Ala 189
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >98% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles.No activity loss is observed after storage at:4-8 centigrade for 12 months in lyophilized state;-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile deionized water. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the COA.
Gene Name : Kitl kit ligand [ Mus musculus ]
Official Symbol : Kitl
Synonyms : KITL; kit ligand; cloud gray; C-kit ligand; Steel factor; grizzle-belly; stem cell factor; mast cell growth factor; hematopoietic growth factor KL; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; Kitlg; contrasted;
Gene ID : 17311
mRNA Refseq : NM_013598
Protein Refseq : NP_038626
UniProt ID : P20826
Chromosome Location : 10 D1; 10 51.4 cM
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific biosystem; Melanogenesis, organism-specific biosystem; Melanogenesis, conserved biosystem;
Function : cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does KITLG influence stem cell factor (SCF) signaling pathways? 11/10/2022

Overexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.

What are the implications of KITLG in oncogenesis and tumor progression? 07/20/2022

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

What role does KITLG play in melanogenesis and pigmentation? 01/17/2022

Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.

Are there any known disorders associated with mutations or dysregulation of KITLG? 06/22/2020

Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.

What is the primary biological function of KITLG in the hematopoietic system? 04/12/2020

KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.

How has KITLG been explored as a therapeutic target or agent in clinical settings? 02/10/2020

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

How does KITLG interact with its receptor, c-KIT? 12/21/2019

KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.

Customer Reviews (3)

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Reviews
01/23/2022

    Reliable for immunoprecipitation assay.

    03/01/2021

      No contamination, very clean.

      02/09/2020

        Worked perfectly in Western.

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