Active Recombinant Human LRRK2 (R1441C) Protein, GST-tagged
Cat.No. : | LRRK2-112H |
Product Overview : | Recombinant human LRRK2 (R1441C) (968-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease with prevalent mutations being found within the GTPase and kinase domains. LRRK2 cooperates with MET to promote efficient tumor cell growth and survival in various cancers. Down-regulation of LRRK2 in cultured tumor cells compromises MET activation and selectively reduces downstream MET signaling to mTOR and STAT3. |
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 6 nmol/min/mg |
Molecular Mass : | ~210 kDa |
Purity : | >70 % |
Stability : | 1 Year at -70 centigrade |
Storage : | Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05 μg/μL |
Protein length : | 968-end |
Gene Name : | LRRK2 leucine-rich repeat kinase 2 [ Homo sapiens ] |
Official Symbol : | LRRK2 |
Synonyms : | LRRK2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN |
Gene ID : | 120892 |
mRNA Refseq : | NM_198578 |
Protein Refseq : | NP_940980 |
MIM : | 609007 |
UniProt ID : | Q5S007 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt has an inhibitory or killing effect on specific pathogens.
High sensitivity and specificity were found in biosensor preparation.
Good selectivity for specific disease-related targets.
Q&As (6)
Ask a questionLRRK2 gene mutations may play an important role in neurodevelopment, including neural precursor cell fate determination, cell migration, and axon clumping.
In addition to Parkinson's disease, LRRK2 gene mutations are also associated with an increased risk of other diseases, such as Crohn's disease, leukemia and cancer.
By analyzing the clinical and genetic data of a large number of patients, the impact of LRRK2 gene mutations on the prognosis of Parkinson's disease patients, such as age of onset, clinical symptoms, and disease progression, can be evaluated.
LRRK2 gene mutations may complicate the pathogenesis of Parkinson's disease, including increased apoptosis, affecting vesicles, mitochondria, and autophagy function.
Drugs that inhibit LRRK2 protein have potential value in the treatment of Parkinson's disease, but are still in clinical research and further research is needed on their efficacy and safety.
The function and regulation of LRRK2 can be studied using different research methods such as cell culture models, mouse models, fruit fly models, and human induced pluripotent stem cells.
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