Active Recombinant Human TGFBR1 protein, His&hFc-tagged

• Cat.No.: TGFBR1-2346H
• Product Overview: Recombinant Human TGFBR1 protein(NP_004603.1)(Met1-Glu125), fused with His&hFc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His&Fc
• Form: Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Bio-activity: 1. Measured by its binding ability in a functional ELISA. Immobilized mouse CD105 at 10 μg/ml (100 μl/well) can bind human TGFRB1 with a linear range of 6.4-800 ng/ml.2. Measured by its ability to bind human CD105 in a functional ELISA.
• Molecular Mass: The recombinant human TGFBR1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 340 amino acids and has a predicted molecular mass of 38.1 kDa. As a result of glycosylation, the apparent molecular mass of rh TGFBR1/Fc monomer is approximately 45-50 kDa in SDS-PAGE under reducing conditions, with ~10% free Fc fragments.
• Protein length: Met1-Glu125
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 85 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
  Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
• Official Symbol: TGFBR1
• Synonyms: TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1
• Gene ID: 7046
• mRNA Refseq: NM_001130916
• Protein Refseq: NP_001124388
• MIM: 190181
• UniProt ID: P36897

Reviews

07/19/2021

Easy to purify and high purity in production.

04/22/2021

The protein has strong reducibility.

02/17/2021

He did well in the ELISA test.

Q&As

How can the information of TGFBR1 be used for the development of therapeutic strategies?

In-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.

Are gene polymorphisms in TGFBR1 associated with disease susceptibility?

Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.

Is TGFBR1 associated with diseases of the skeletal system?

Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.

What is the role of the TGFBR1 pathway in liver disease?

The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.

What are the inhibitors of TGFBR1?

Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.

What is the relationship between TGFBR1 and kidney disease?

TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.