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Recombinant Human MYD88, His-tagged

Cat.No. : MYD88-7112H
Product Overview : Recombinant human MYD88 protein, fused to His-tag at N-terminus, was expressed in E.coli.
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  • Gene Information
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Description : Myeloid differentiation primary response gene 88, also known as MYD88, acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Molecular Mass : 38.7kDa (345aa)
Protein length : 1-309aa
AA Sequence : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRPD RAEAPGPPAM AAGGPGAGSA APVSSTSSLP LAALNMRVRR RLSLFLNVRT QVAADWTALA EEMDFEYLEI RQLETQADPT GRLLDAWQGR PGASVGRLLE LLTKLGRDDV LLELGPSIEE DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml
Gene Name : MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ]
Official Symbol : MYD88
Synonyms : MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D;
Gene ID : 4615
mRNA Refseq : NM_001172566
Protein Refseq : NP_001166037
MIM : 602170
UniProt ID : Q99836
Chromosome Location : 3p22
Pathway : Activated TLR4 signalling, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function : TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MYD88 contribute to the formation of the Myddosome complex in TLR signaling? 12/13/2021

MYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.

How is the expression of the MYD88 gene regulated at the molecular level? 06/26/2020

MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.

Explain the role of MYD88 in the recognition of microbial components by the immune system. 03/09/2019

MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.

What are the downstream signaling pathways activated by MYD88, and how do they influence immune responses? 10/26/2018

MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.

Explain the role of MYD88 in adaptive immunity and its crosstalk with T and B cell responses. 05/01/2018

MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.

Customer Reviews (3)

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Reviews
02/26/2022

    Top-tier service—customer support's expertise ensured the perfect protein fit.

    01/09/2019

      Dependable quality and service—this recombined protein is a lab favorite.

      05/23/2018

        Rapid delivery, precise results—this product is a lab essential.

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