Recombinant Human MYD88, His-tagged
Cat.No. : | MYD88-7112H |
Product Overview : | Recombinant human MYD88 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | Myeloid differentiation primary response gene 88, also known as MYD88, acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol |
Molecular Mass : | 38.7kDa (345aa) |
Protein length : | 1-309aa |
AA Sequence : | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRPD RAEAPGPPAM AAGGPGAGSA APVSSTSSLP LAALNMRVRR RLSLFLNVRT QVAADWTALA EEMDFEYLEI RQLETQADPT GRLLDAWQGR PGASVGRLLE LLTKLGRDDV LLELGPSIEE DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml |
Gene Name : | MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ] |
Official Symbol : | MYD88 |
Synonyms : | MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D; |
Gene ID : | 4615 |
mRNA Refseq : | NM_001172566 |
Protein Refseq : | NP_001166037 |
MIM : | 602170 |
UniProt ID : | Q99836 |
Chromosome Location : | 3p22 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; |
Function : | TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
MYD88-0071H | Recombinant Human MYD88 Protein (M157-P296), Tag Free | +Inquiry |
Myd88-4241M | Recombinant Mouse Myd88 Protein, Myc/DDK-tagged | +Inquiry |
MYD88-1147C | Recombinant Chicken MYD88 Protein, His-tagged | +Inquiry |
MYD88-2737R | Recombinant Rhesus Macaque MYD88 Protein, His (Fc)-Avi-tagged | +Inquiry |
MYD88-3502R | Recombinant Rat MYD88 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MYD88-4034HCL | Recombinant Human MYD88 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.
MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.
MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.
MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.
MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.
Customer Reviews (3)
Write a reviewTop-tier service—customer support's expertise ensured the perfect protein fit.
Dependable quality and service—this recombined protein is a lab favorite.
Rapid delivery, precise results—this product is a lab essential.
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