Recombinant Mouse Dpp4, Fc-tagged

• Cat.No.: Dpp4-120M
• Product Overview: A DNA sequence encoding the mouse Dpp4 (Ser29-His760) was expressed with the Fc region of human IgG1 at the N-terminus.

Specification

• Description: Dipeptidyl Peptidase IV (DPPIV)/CD26, is a highly conserved type I I integral membrane protein associated with immune regulation, signal transduction and apoptosis, and is constitutively expressed on a wide variety of epithelial, endothelial, and lymphoid cell types. DPPIV is a serine exopeptidase catalyzing the cleavage of N-terminal Xaa-Pro dipeptides from peptides, and its substrates include growth factors, chemokines, neuropeptides, and vasoactive peptides. As a T cell-activating molecule (THAM), DPPIV plays important roles in the T cell-mediated immune responses through the regulation of differentiation and growth of T lymphocytes , and also probably acts as a cofactor for entry of HIV in CD4+ cells. Furthermore, DPPIV appears to work as a suppressor in the progression of certain tumors, and also exerts actions in glucose metabolism via interaction with glucagons. DPPIV also binds the enzyme adenosine deaminase specifically with high affinity. Elevated expression of DPPIV is associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The levels of DPPIV soluble form in serum and body fluids have clinical significance in patients with cancer, liver, kidney diseases and depression.
• Source: Human Cells
• Species: Mouse
• Tag: Fc
• Predicted N Terminal: Glu
• Form: Lyophilized from sterile PBS, pH 7.4.
• Molecular Mass: The recombinant mouse Dpp4 consists 992 amino acids and predicts a molecular mass of 112.9 kDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]
• Official Symbol: Dpp4
• Synonyms: Dpp4; Cd26; THAM; Dpp-4; dipeptidylpeptidase 4; dipeptidyl peptidase 4; DPP IV; dipeptidyl peptidase IV; thymocyte-activating molecule; T-cell activation antigen CD26; NP_001153015.1; EC 3.4.14.5; NP_034204.1
• Gene ID: 13482
• mRNA Refseq: NM_010074
• Protein Refseq: NP_034204
• UniProt ID: P28843
• Chromosome Location: 2 C2-D; 2 35.85 cM
• Pathway: Incretin Synthesis, Secretion, and Inactivation; Metabolism of proteins; Protein digestion and absorption
• Function: aminopeptidase activity; dipeptidyl-peptidase activity; identical protein binding

Reviews

09/13/2019

Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

01/27/2019

By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

12/14/2016

Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

Q&As

How does DPP4 relate to diabetes?

DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

Are there any side effects associated with DPP4 inhibitors?

Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

What clinical applications does DPP4 have in managing type 2 diabetes?

Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

Can DPP4 inhibitors be used as a monotherapy for diabetes?

DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

How do DPP4 inhibitors differ from other diabetes medications?

DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.