Recombinant Full Length Human DPP4 Protein, C-Flag-tagged

• Cat.No.: DPP4-797HFL
• Product Overview: Recombinant Full Length Human DPP4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 88.1 kDa
• AA Sequence: MKTPWKVLLGLLGAAALVTIITVPV VLLNKGTDDATADSRKTYTLTDYLK NTYRLKLYSLRWISDHEYLY KQENNILVFNAEYGNSSVFLENSTF DEFGHSINDYSISPDGQFILLEYNY VKQWRHSYTASYDIYDLNKR QLITEERIPNNTQWVTWSPVGHKLA YVWNNDIYVKIEPNLPSYRITWTGK EDIIYNGITDWVYEEEVFSA YSALWWSPNGTFLAYAQFNDTEVPL IEYSFYSDESLQYPKTVRVPYPKAG AVNPTVKFFVVNTDSLSSVT NATSIQITAPASMLIGDHYLCDVTW ATQERISLQWLRRIQNYSVMDICDY DESSGRWNCLVARQHIEMST TGWVGRFRPSEPHFTLDGNSFYKII SNEEGYRHICYFQIDKKDCTFITKG TWEVIGIEALTSDYLYYISN EYKGMPGGRNLYKIQLSDYTKVTCL SCELNPERCQYYSVSFSKEAKYYQL RCSGPGLPLYTLHSSVNDKG LRVLEDNSALDKMLQNVQMPSKKLD FIILNETKFWYQMILPPHFDKSKKY PLLLDVYAGPCSQKADTVFR LNWATYLASTENIIVASFDGRGSGY QGDKIMHAINRRLGTFEVEDQIEAA RQFSKMGFVDNKRIAIWGWS YGGYVTSMVLGSGSGVFKCGIAVAP VSRWEYYDSVYTERYMGLPTPEDNL DHYRNSTVMSRAENFKQVEY LLIHGTADDNVHFQQSAQISKALVD VGVDFQAMWYTDEDHGIASSTAHQH IYTHMSHFIKQCFSLPTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane

Gene Information

• Gene Name: DPP4 dipeptidyl peptidase 4 [ Homo sapiens (human) ]
• Official Symbol: DPP4
• Synonyms: CD26; ADABP; ADCP2; DPPIV; TP103
• Gene ID: 1803
• mRNA Refseq: NM_001935.4
• Protein Refseq: NP_001926.2
• MIM: 102720
• UniProt ID: P27487