Active Recombinant Mouse Pdgfa
Cat.No. : | Pdgfa-304M |
Product Overview : | PDGF-AA Mouse Recombinant is a disulfide linked homodimeric, non-glycosylated, polypeptide chain containing 2 x 126 amino acids and having a total molecular mass of 28.9 kDa. PDGF-AA is purified by proprietary chromatographic techniques. |
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Description : | PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. |
Source : | E. Coli |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. The protein was lyophilized with no additives. |
Bio-activity : | Established by the dose-dependent stimulation of Balb/c 3T3 cells proliferation. The expected ED50 for this effect is 8-10 ng/ml corresponding to a specific activity of 100,000-125,000IU/mg. |
AA Sequence : | MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATSNLN PDHREEETGR RRESGKNRKR KRLKPT. |
Purity : | Greater than 97.0% as determined by RP-HPLC and SDS-PAGE. |
Storage : | Lyophilized PDGF-AA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PDGF-AA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Publication : |
MiR-34a regulates Migration of Mouse Lung Fibroblasts by modulating PDGFR signalling (2019)
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Gene Name : | Pdgfa platelet derived growth factor, alpha [ Mus musculus (house mouse) ] |
Official Symbol : | Pdgfa |
Synonyms : | Pdgfa; PDGF-1; platelet derived growth factor, alpha; platelet-derived growth factor subunit A; PDGF subunit A; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide |
Gene ID : | 18590 |
mRNA Refseq : | NM_008808 |
Protein Refseq : | NP_032834 |
UniProt ID : | P20033 |
Chromosome Location : | 5 G2; 5 77.65 cM |
Pathway : | Adaptive Immune System; Cytokine-cytokine receptor interaction; Cytokines and Inflammatory Response (BioCarta) |
Function : | growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding |
Products Types
◆ Recombinant Protein | ||
PDGFA-2570H | Recombinant Human PDGFA Protein, His-tagged | +Inquiry |
PDGFA-6594M | Recombinant Mouse PDGFA Protein, His (Fc)-Avi-tagged | +Inquiry |
Pdgfa-4755M | Active Recombinant Mouse Pdgfa Protein | +Inquiry |
Pdgfa-317P | Active Recombinant Mouse Pdgfaa Protein (125 aa) | +Inquiry |
PDGFA-222H | Active Recombinant Human PDGF-AB Protein | +Inquiry |
◆ Lysates | ||
PDGFA-3337HCL | Recombinant Human PDGFA 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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