Recombinant Cynomolgus Monkey PCNA Protein, His (Fc)-Avi-tagged

• Cat.No.: PCNA-518C
• Product Overview: Recombinant Cynomolgus Monkey PCNA with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Cynomolgus Monkey
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: PCNA proliferating cell nuclear antigen [ Macaca fascicularis (crab-eating macaque) ]
• Official Symbol: PCNA
• Synonyms: PCNA
• Gene ID: 102124021
• mRNA Refseq: NM_001287720
• Protein Refseq: NP_001274649
• UniProt ID: P61258

Reviews

01/04/2023

In protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

06/17/2017

In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

04/07/2016

I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.

Q&As

Can PCNA levels in tumor tissues provide prognostic information for cancer patients?

Yes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.

Are there any genetic mutations associated with PCNA that impact clinical outcomes?

Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.

How is PCNA protein relevant in cancer diagnosis and treatment?

PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.

Are there any PCNA-targeted therapies currently in clinical trials or use?

Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.

How is PCNA protein involved in DNA repair pathways, and how is this relevant to clinical applications

PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.