Recombinant Full Length Human BPIFA1 Protein, C-Flag-tagged

• Cat.No.: BPIFA1-989HFL
• Product Overview: Recombinant Full Length Human BPIFA1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 24.6 kDa
• AA Sequence: MFQTGGLIVFYGLLAQTMAQFGGLP VPLDQTLPLNVNPALPLSPTGLAGS LTNALSNGLLSGGLLGILEN LPLLDILKPGGGTSGGLLGGLLGKV TSVIPGLNNIIDIKVTDPQLLELGL VQSPDGHRLYVTIPLGIKLQ VNTPLVGASLLRLAVKLDITAEILA VRDKQERIHLVLGDCTHSPGSLQIS LLDGLGPLPIQGLLDSLTGI
  LNKVLPELVQGNVCPLVNEVLRGLD ITLVHDIVNMLIHGLQFVIKVTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Secreted Protein

Gene Information

• Gene Name: BPIFA1 BPI fold containing family A member 1 [ Homo sapiens (human) ]
• Official Symbol: BPIFA1
• Synonyms: LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
• Gene ID: 51297
• mRNA Refseq: NM_016583.4
• Protein Refseq: NP_057667.1
• MIM: 607412
• UniProt ID: Q9NP55

Reviews

02/11/2022

researchers using thearnE protein can benefit from its high purity and quality, ensuring reliable results.

03/02/2018

This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

08/20/2017

the BPIFA1 protein is available in different formats, including recombinant and purified variants.

Q&As

How is BPIFA1 protein linked to chronic obstructive pulmonary disease (COPD)?

Studies have suggested that BPIFA1 protein expression is decreased in the airways of COPD patients, and it may play a role in the pathogenesis of the disease.

Is there a genetic component to BPIFA1 protein expression?

Genetic variations in the BPIFA1 gene have been associated with altered BPIFA1 protein expression and may contribute to individual susceptibility to respiratory diseases.

Can BPIFA1 protein levels be influenced by environmental factors?

Environmental factors such as air pollution and cigarette smoke have been shown to impact BPIFA1 protein expression in the airways, potentially contributing to respiratory disease pathogenesis.

Are there any diagnostic assays available for measuring BPIFA1 protein levels?

Several research groups have developed assays for quantifying BPIFA1 protein levels in respiratory samples, but these assays are still under investigation for clinical use.

What animal models are used to study BPIFA1 protein function?

Mouse models with BPIFA1 gene knockout or overexpression have been instrumental in elucidating the physiological roles of BPIFA1 protein in the respiratory tract.