Recombinant Full Length Human GLUD1 Protein, C-Flag-tagged
Cat.No. : | GLUD1-1278HFL |
Product Overview : | Recombinant Full Length Human GLUD1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 56 kDa |
AA Sequence : | MYRYLGEALLLSRAGPAALGSASAD SAALLGWARGQPAAAPQPGLALAAR RHYSEAVADREDDPNFFKMV EGFFDRGASIVEDKLVEDLRTRESE EQKRNRVRGILRIIKPCNHVLSLSF PIRRDDGSWEVIEGYRAQHS QHRTPCKGGIRYSTDVSVDEVKALA SLMTYKCAVVDVPFGGAKAGVKINP KNYTDNELEKITRRFTMELA KKGFIGPGIDVPAPDMSTGEREMSW IADTYASTIGHYDINAHACVTGKPI SQGGIHGRISATGRGVFHGI ENFINEASYMSILGMTPGFGDKTFV VQGFGNVGLHSMRYLHRFGAKCIAV GESDGSIWNPDGIDPKELED FKLQHGSILGFPKAKPYEGSILEAD CDILIPAASEKQLTKSNAPRVKAKI IAEGANGPTTPEADKIFLER NIMVIPDLYLNAGGVTVSYFEWLKN LNHVSYGRLTFKYERDSNYHLLMSV QESLERKFGKHGGTIPIVPT AEFQDRISGASEKDIVHSGLAYTME RSARQIMRTAMKYNLGLDLRTAAYV NAIEKVFKVYNEAGVTFTTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, D-Glutamine and D-glutamate metabolism, Metabolic pathways, Nitrogen metabolism |
Gene Name : | GLUD1 glutamate dehydrogenase 1 [ Homo sapiens (human) ] |
Official Symbol : | GLUD1 |
Synonyms : | GDH; GDH1; GLUD; hGDH1 |
Gene ID : | 2746 |
mRNA Refseq : | NM_005271.5 |
Protein Refseq : | NP_005262.1 |
MIM : | 138130 |
UniProt ID : | P00367 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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