Recombinant Full Length Human Tryptophan 5-Hydroxylase 2(Tph2) Protein, His-Tagged

• Cat.No.: RFL3499HF
• Product Overview: Recombinant Full Length Human Tryptophan 5-hydroxylase 2(TPH2) Protein (Q8IWU9) (1-490aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-490aa)
• AA Sequence: MQPAMMMFSSKYWARRGFSLDSAVP EEHQLLGSSTLNKPNSGKNDDKGNK GSSKREAATESGKTAVVFSLKNEVG GLVKALRLFQEKRVNMVHIESRKSR RRSSEVEIFVDCECGKTEFNELIQL LKFQTTIVTLNPPENIWTEEEELED VPWFPRKISELDKCSHRVLMYGSEL DADHPGFKDNVYRQRRKYFVDVAMG YKYGQPIPRVEYTEEETKTWGVVFR ELSKLYPTHACREYLKNFPLLTKYC GYREDNVPQLEDVSMFLKERSGFTV RPVAGYLSPRDFLAGLAYRVFHCTQ YIRHGSDPLYTPEPDTCHELLGHVP LLADPKFAQFSQEIGLASLGASDED VQKLATCYFFTIEFGLCKQEGQLRA YGAGLLSSIGELKHALSDKACVKAF DPKTTCLQECLITTFQEAYFVSESF EEAKEKMRDFAKSITRPFSVYFNPY TQSIEILKDTRSIENVVQDLRSDLN TVCDALNKMNQYLGI Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: TPH2
• Synonyms: TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
• UniProt ID: Q8IWU9

Gene Information

• Gene Name: TPH2
• Synonyms: TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
• UniProt ID: Q8IWU9

Reviews

01/22/2021

Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.

11/10/2018

The TPH2 protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.

01/24/2018

The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.

Q&As

How can TPH2 be targeted for therapeutic interventions?

Targeting TPH2 through pharmacological agents or gene therapies may be explored to modulate serotonin levels and alleviate mood disorders.

What role does TPH2 play in anxiety disorders?

TPH2 dysregulation may lead to imbalances in serotonin, contributing to the pathogenesis of anxiety disorders.

How does TPH2 relate to neurodegenerative disorders?

TPH2 has been studied in the context of neurodegenerative disorders due to its influence on serotonin, which has neuroprotective properties.

Can TPH2 be a target for drug development in psychiatry?

Yes, drugs targeting TPH2 or the serotonin pathway are being investigated for their potential in developing novel psychiatric medications.

Are there genetic factors influencing TPH2 expression?

Yes, genetic variations can affect TPH2 expression, contributing to individual differences in serotonin levels and susceptibility to mood disorders.