Recombinant Full Length Nasalis Larvatus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged

• Cat.No.: RFL17469NF
• Product Overview: Recombinant Full Length Nasalis larvatus C-C chemokine receptor type 5(CCR5) Protein (Q95NC7) (1-352aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Nasalis larvatus (Proboscis monkey)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-352)
• AA Sequence: MDYQVSSPTYDIDYYTSEPCQKVNV KQIAARLLPPLYSLVFIFGFVGNIL VVLILINCKR LKSMTDIYLLNLAISDLFFLLTVPF WAHYAAARWDFGNTMCQLLTGLYFI GFFSGIFFII LLTIDRYLAIVHAVFALKARTVTFG VVTSVITWVVAVFASLPGIIFTRSQ REGLHYTCSS HFPYSQYQFWKNFQTLKIVILGLVL PLLVMVICYSGILKTLLRCRNEKKR HRAVRLIFTI MIVYFLFWAPYNIVLLLNTFQEFFG LNNCSSSNRLDQAMQVTETLGMTHC CINPIIYAFV GEKFRNYLLVFFQKHIAKRFCKCCS IFQQEAPERASSVYTRSTGEQEISV GL
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: CCR5
• Synonyms: CCR5; CMKBR5; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CD antigen CD195
• UniProt ID: Q95NC7

Gene Information

• Gene Name: CCR5
• Synonyms: CCR5; CMKBR5; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CD antigen CD195
• UniProt ID: Q95NC7

Reviews

04/04/2023

When experiments are performed with CCR5, stable and reproducible results can be obtained.

01/13/2023

CCR5 has a high yield and good economic benefits.

07/12/2022

CCR5 exerts the expected biological effects in experiments.

Q&As

What is the main function of CCR5 protein in the human body?

In the human body, CCR5 protein is mainly involved in the regulation of the immune system, it acts as a chemokine receptor, which can sense the signal of the site of inflammation and guide immune cells to reach the site of inflammation, thus playing a role in immune response.

How about the unsolved questions or future research directions for CCR5 protein?

There are still many unsolved questions and future research directions for CCR5 protein. For example, we need to better understand the structure-function relationship of CCR5, explore the interaction of CCR5 with other proteins and their potential implications, and develop more potent and selective CCR5 antagonists.

In immunotherapy, how to use the function of CCR5 for disease treatment?

In immunotherapy, the function of CCR5 can be used for disease treatment, such as affecting the migration and activation of immune cells by regulating the expression or function of CCR5, so as to achieve the purpose of treating inflammatory diseases or autoimmune diseases. In addition, antibodies or antagonists against CCR5 may also be considered to inhibit its binding to ligands to further modulate the immune response.

What is the interaction of CCR5 protein with other receptors or signaling pathways?

CCR5 protein can interact with other receptors and signaling pathways. For example, in some cancer cells, CCR5 binds to EGFR (epidermal growth factor receptor), triggering EGFR activation and promoting tumor cell growth and metastasis. In addition, CCR5 is also involved in the regulation of signaling pathways such as MAPK (mitogen-activated protein kinase) and PI3K (phosphatidylinositol kinase).

How can gene editing technology be used to modify or treat the CCR5 gene?

Gene editing technology such as CRISPR-Cas9 can be used to modify or treat the CCR5 gene. By editing the CCR5 gene, the expression of CCR5 protein can be regulated or its function can be changed. This technique is expected to be used in the future to treat some genetic diseases or cancers associated with CCR5.

How can CCR5 protein be used for disease treatment?

One way to use CCR5 protein for disease treatment is to use CCR5 antagonists, which are drugs that prevent CCR5 from binding to ligands. There are already a number of CCR5 antagonists in clinical trials for the treatment of diseases such as AIDS and rheumatoid arthritis.