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Recombinant Human AQP11 293 Cell Lysate

Cat.No. : AQP11-8768HCL
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Description : Antigen standard for aquaporin 11 (AQP11) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : AQP11 aquaporin 11 [ Homo sapiens ]
Official Symbol : AQP11
Synonyms : AQPX1
Gene ID : 282679
mRNA Refseq : NM_173039.2
Protein Refseq : NP_766627.1
MIM : 609914
UniProt ID : Q8NBQ7
Chromosome Location : 11q14.1
Function : molecular_function;transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Can AQP11 be a potential therapeutic target for certain diseases? 02/21/2023

AQP11 has the potential to be a therapeutic target for certain diseases, particularly those involving impaired kidney function. Understanding its precise role in various pathological conditions could provide insights into developing therapies that target its activity or expression. However, further research is needed to determine its therapeutic potential and develop specific interventions.

Are there any known therapeutic strategies for AQP11-related disorders? 11/21/2022

Currently, there are no specific therapeutic strategies targeting AQP11-related disorders. However, ongoing research aimed at understanding the protein's function and mechanisms of disease could potentially lead to the development of targeted treatments in the future.

Are there any known interactions between AQP11 and other proteins? 12/08/2021

While the specific protein interactions of AQP11 are still being explored, some studies have reported potential interactions between AQP11 and other aquaporins, as well as with proteins involved in cellular processes such as vesicular trafficking and ion transport.

Does AQP11 play a role in fluid homeostasis? 10/19/2021

AQP11 has been implicated in fluid homeostasis, particularly in the kidneys. It is involved in the reabsorption and regulation of water and solutes, contributing to the maintenance of the body's fluid balance. Dysfunction of AQP11 can disrupt fluid homeostasis and lead to water balance disorders.

Does AQP11 have any role in cancer progression or metastasis? 10/16/2021

Currently, there is limited research exploring the role of AQP11 in cancer progression and metastasis. While aquaporins, in general, have been implicated in various aspects of tumor biology, such as angiogenesis and cell migration, the specific involvement of AQP11 in cancer is not well understood. Further studies are needed to determine if AQP11 plays a role in cancer development, progression, or metastasis.

Are there any therapeutic implications of studying the AQP11 protein? 02/18/2021

Understanding the role of the AQP11 protein and its associated genetic disorders could potentially lead to the development of targeted therapies for kidney-related conditions in the future.

Are there any drugs or therapies targeting AQP11 under development? 10/23/2020

Currently, there are no specific drugs or therapies targeting AQP11 that are under development. However, the potential importance of aquaporins in various diseases has prompted the search for aquaporin-modulating agents. These agents may impact AQP11 function indirectly, although their effectiveness and specificity on AQP11 need to be determined. Developing targeted therapies for AQP11-related disorders is an area of ongoing research and may hold promise in the future.

What research is being conducted to further explore the AQP11 protein? 05/21/2020

Ongoing research is focused on elucidating the precise mechanisms of AQP11 protein function, identifying its interacting partners, and exploring its involvement in various physiological processes and diseases.

Can AQP11 deficiency lead to any health problems? 05/07/2020

Yes, AQP11 deficiency has been associated with several health problems. Studies have shown that mice lacking AQP11 exhibit abnormalities in kidney function, including reduced water reabsorption and altered excretion of solutes. AQP11 mutations in humans have also been linked to kidney diseases and impaired renal function.

What are the consequences of AQP11 dysfunction? 02/17/2020

The consequences of AQP11 dysfunction can vary depending on the specific mutation or deficiency. However, studies have shown that AQP11 dysfunction can lead to impaired water and solute transport in the kidney, resulting in disorders such as nephrogenic diabetes insipidus and kidney dysfunction. AQP11 dysfunction has also been associated with liver fibrosis, neurodegenerative diseases, and possibly other health problems that are still being explored.

Are there any genetic disorders associated with AQP11 protein mutations? 12/27/2019

Yes, mutations in the AQP11 gene have been associated with certain kidney-related disorders, such as nephrogenic diabetes insipidus and polycystic kidney disease.

Can changes in AQP11 expression be seen under certain pathological conditions? 08/08/2018

Yes, studies have shown that AQP11 expression can be altered under pathological conditions. For example, increased expression of AQP11 has been observed in the kidneys of diabetic mice, suggesting a potential role in diabetic nephropathy. Additionally, changes in AQP11 expression have been reported in liver fibrosis and neurodegenerative diseases.

Are there any known AQP11-related disorders besides kidney and liver diseases? 02/04/2018

While kidney and liver diseases are the most well-studied AQP11-related disorders, emerging evidence suggests potential involvement of AQP11 in other conditions. For example, altered AQP11 expression has been reported in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. More research is needed to determine the extent of AQP11's involvement in these disorders and whether it plays a role in other health conditions.

Are there any known small molecule modulators of AQP11 activity? 01/26/2017

Currently, there are no specific small molecule modulators of AQP11 activity that have been identified. However, there have been efforts to develop pharmacological agents targeting aquaporins in general, which could potentially impact AQP11 function. These include drugs designed to inhibit or activate aquaporins, but their effectiveness on AQP11 specifically remains to be determined.

Does the AQP11 protein have any role in the brain? 12/30/2016

Yes, the AQP11 protein has been detected in certain regions of the brain, particularly in the hippocampus and cerebral cortex. While its exact function in the brain is not well understood, it is believed to be involved in the regulation of water and solute transport within brain cells.

Can AQP11 be used as a biomarker for certain diseases? 10/03/2016

AQP11 has the potential to serve as a biomarker for certain diseases, particularly those affecting the kidney or liver. Altered expression levels of AQP11 have been observed in kidney disorders, such as nephrogenic diabetes insipidus, and in liver diseases, such as liver fibrosis. However, more research is needed to validate its use as a biomarker and determine its clinical utility in disease diagnosis, prognosis, or treatment response.

Can AQP11 mutations lead to the development of genetic diseases? 06/03/2016

AQP11 mutations have been associated with the development of genetic diseases, particularly those affecting the kidneys. Nephrogenic diabetes insipidus (NDI) is one such disorder that can be caused by AQP11 mutations. These mutations can lead to dysfunctional water and solute transport in the renal tubules, resulting in impaired urine concentration and excessive thirst. Further research is needed to understand the full spectrum of genetic diseases that can arise from AQP11 mutations.

How does the AQP11 protein differ from other aquaporins? 04/08/2016

The AQP11 protein differs from other aquaporins in terms of its subcellular localization and function. Unlike other aquaporins that are primarily found in plasma membranes, AQP11 is localized in the intracellular organelles such as the endoplasmic reticulum and mitochondria.

Customer Reviews (4)

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Reviews
03/04/2022

    The outstanding performance of AQP11 protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.

    09/19/2020

      Whether it is protein-protein interactions, enzymatic assays, or cellular studies, AQP11 protein delivers consistent and accurate data, making it a valuable tool for researchers.

      04/06/2018

        By incorporating AQP11 protein into electron microscopy studies, researchers have gained valuable insights into protein interactions and conformational changes, contributing to a deeper understanding of complex cellular processes.

        02/21/2017

          Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.

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