Recombinant Human CADM3 Protein, His-tagged

• Cat.No.: CADM3-113H
• Product Overview: Recombinant human CADM3 protein with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 34.5 kDa
• Protein length: 398
• AA Sequence: MGAPAASLLLLLLLFACCWAPGGAN LSQDDSQPWTSDETVVAGGTVVLKC QVKDHEDSSLQWSNPAQQTLYFGEK RALRDNRIQLVTSTPHELSISISNV ALADEGEYTCSIFTMPVRTAKSLVT VLGIPQKPIITGYKSSLREKDTATL NCQSSGSKPAARLTWRKGDQELHGE PTRIQEDPNGKTFTVSSSVTFQVTR EDDGASIVCSVNHESLKGADRSTSQ RIEVLYTPTAMIRPDPPHPREGQKL LLHCEGRGNPVPQQYLWEKEGSVPP LKMTQESALIFPFLNKSDSGTYGCT ATSNMGSYKAYYTLNVNDPSPVPSS SSTYHAIIGGIVAFIVFLLLIMLIF LGHYLIRHKGTYLTHEAKGSDDAPD ADTAIINAEGGQSGGDDKKEYFI
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: CADM3 cell adhesion molecule 3 [ Homo sapiens (human) ]
• Official Symbol: CADM3
• Synonyms: CADM3; cell adhesion molecule 3; IGSF4B, immunoglobulin superfamily, member 4B; BIgR; FLJ10698; Necl 1; NECL1; nectin like 1; SynCAM3; TSLL1; TSLC1-like 1; nectin-like 1; TSLC1-like protein 1; nectin-like protein 1; brain immunoglobulin receptor; synaptic cell adhesion molecule 3; immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Necl-1; synCAM3
• Gene ID: 57863
• mRNA Refseq: NM_001127173
• Protein Refseq: NP_001120645
• MIM: 609743
• UniProt ID: Q8N126

Reviews

08/04/2022

The product's quality is exceptional.

03/21/2020

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01/27/2018

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Q&As

What are the implications of CADM3 mutations or dysregulation in neurological diseases like autism or schizophrenia?

Mutations or dysregulation of CADM3 have been linked to neurological disorders like autism spectrum disorders and schizophrenia, highlighting its significance in neural function.

Can you explain the structure of CADM3 and its interactions with other proteins or ligands in neural adhesion processes?

CADM3 has extracellular domains responsible for adhesion. It interacts with other synaptic proteins like neurexins and neuroligins, contributing to synaptic adhesion and signaling.

How does CADM3 contribute to synaptic adhesion and plasticity, and why is this important for neurological research?

CADM3 mediates synaptic adhesion and facilitates synaptic plasticity, which is essential for learning and memory processes. Understanding CADM3's role is critical for advancing our knowledge of neurological disorders and cognitive function.

What is the primary function of CADM3 in cellular processes, and where is it typically expressed in the body?

CADM3, also known as SynCAM3, is a cell adhesion molecule that plays a crucial role in synapse formation and neural connectivity. It is primarily expressed in neural tissues, particularly in neurons.

How does CADM3 expression change during brain development, and what roles does it play in neural differentiation and circuit formation?

CADM3 expression varies during brain development and contributes to neural differentiation and circuit formation, aiding in proper brain function.