Recombinant Human CSE1L protein, MYC/DDK-tagged
Cat.No. : | CSE1L-9523H |
Product Overview : | Recombinant Human CSE1L fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
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Description : | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 110.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ] |
Official Symbol : | CSE1L |
Synonyms : | CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037; |
Gene ID : | 1434 |
mRNA Refseq : | NM_001316 |
Protein Refseq : | NP_001307 |
MIM : | 601342 |
UniProt ID : | P55060 |
Chromosome Location : | 20q13 |
Pathway : | Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem; |
Function : | importin-alpha export receptor activity; protein binding; protein transporter activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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