Recombinant Human CYR61 Protein, His-tagged

• Cat.No.: CYR61-436H
• Product Overview: Recombinant Human CYR61(Leu178~Asp381) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 26.9kDa
• Protein length: Leu178~Asp381
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 92%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens ]
• Official Symbol: CYR61
• Synonyms: CYR61; cysteine-rich, angiogenic inducer, 61; IGFBP10; protein CYR61; CCN1; GIG1; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10
• Gene ID: 3491
• mRNA Refseq: NM_001554
• Protein Refseq: NP_001545
• MIM: 602369
• UniProt ID: O00622

Reviews

07/18/2022

It has good effect and stability in gene expression regulation.

06/04/2022

Will not interact with other drugs, will not affect.

07/20/2021

The application performance is stable in common colorimetric reactions.

Q&As

What did recent research on CYR61 find?

Recent studies have found that CYR61 plays an important role in tumor development and metastasis, especially in cancers such as non-small cell lung cancer, breast cancer, gastric cancer, and colorectal cancer.

Which drugs can inhibit the expression level of CYR61?

There are currently no drugs specifically targeting CYR61, but some anti-tumor drugs can inhibit the expression level of CYR61, such as chemotherapy drugs and targeted therapy drugs.

What is the relationship between the level of CYR61 expression and patient survival?

Studies have shown that high levels of CYR61 expression are associated with decreased patient survival, suggesting that it may be used as a biomarker to predict patient survival.

What signaling pathways is CYR61 involved in?

CYR61 is involved in a variety of signaling pathways, including Wnt, MAPK, ERK, and PI3K.

What is the significance of regulating the expression level of CYR61 for the treatment of diseases?

Regulating the expression level of CYR61 is of great significance for the treatment of diseases, especially for the treatment of cancer, and can slow down the growth and spread of tumors by inhibiting the expression level of CYR61.

How can the relationship between CYR61 expression levels and disease risk be assessed?

The relationship between CYR61 expression levels and disease risk can be assessed by immunohistochemistry or western blot analysis of the patient's tissue samples.