Recombinant Human PENK, His-tagged
Cat.No. : | PENK-177H |
Product Overview : | Recombinant Human Proenkephalin-A/PENK is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu25-Phe267) of Human PENK fused with a polyhistidine tag at the C-terminus. |
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Description : | Proenkephalin-A is a secreted protein that belongs to the opioid neuropeptide precursor family. Proenkephalin-A is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Proenkephalin-A (114-133) and Proenkephalin-A (237-258) increase glutamate release in the striatum. Proenkephalin-A (114-133) decreases GABA concentration in the striatum. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
AA Sequence : | ECSQDCATCSYRLVRPADINFLACV MECEGKLPSLKIWETCKELLQLSKP ELPQDGTSTLRENSK PEESHLLAKRYGGFMKRYGGFMKKM DELYPMEPEEEANGSEILAKRYGGF MKKDAEEDDSLANSS DLLKELLETGDNRERSHHQDGSDNE EEVSKRYGGFMRGLKRSPQLEDEAK ELQKRYGGFMRRVGR PEWWMDYQKRYGGFLKRFAEALPSD EEGESYSKEVPEMEKRYGGFMRFVD HHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Protein length : | Glu25-Phe267 |
Gene Name : | PENK proenkephalin [ Homo sapiens ] |
Official Symbol : | PENK |
Synonyms : | PENK; proenkephalin; proenkephalin-A; preproenkephalin; enkephalin A; |
Gene ID : | 5179 |
mRNA Refseq : | NM_001135690 |
Protein Refseq : | NP_001129162 |
MIM : | 131330 |
UniProt ID : | P01210 |
Chromosome Location : | 8q23-q24 |
Pathway : | Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem; |
Function : | neuropeptide hormone activity; opioid peptide activity; |
Products Types
◆ Recombinant Protein | ||
PENK-1647H | Recombinant Human PENK Protein, His (Fc)-Avi-tagged | +Inquiry |
Penk-4793M | Recombinant Mouse Penk Protein, Myc/DDK-tagged | +Inquiry |
PENK-6634M | Recombinant Mouse PENK Protein, His (Fc)-Avi-tagged | +Inquiry |
PENK-4035R | Recombinant Rat PENK Protein, His (Fc)-Avi-tagged | +Inquiry |
PENK-4375R | Recombinant Rat PENK Protein | +Inquiry |
◆ Lysates | ||
PENK-3298HCL | Recombinant Human PENK 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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