Active Recombinant Full Length Human SFRS Protein Kinase 1, GST-tagged

• Cat.No.: SRPK1-435H
• Product Overview: Recombinant full-length human SRPK1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 130 kDa.

Specification

• Cat. No.: SRPK1-435H
• Description: SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin. SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Hence it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SRPK1 SFRS protein kinase 1 [ Homo sapiens ]
• Synonyms: SRPK1; SFRS protein kinase 1; SFRSK1; SR protein kinase 1; EC 2.7.11.1; SR-protein-specific kinase 1; Serine/arginine-rich protein-specific kinase 1; Serine/threonine-protein kinase SRPK1
• Gene ID: 6732
• mRNA Refseq: NM_003137
• Protein Refseq: NP_003128
• MIM: 601939
• UniProt ID: Q96SB4
• Chromosome Location: 6p21.3-p21.2
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

Reviews

02/02/2023

By using SRPK1 protein, I can gain insights into the underlying molecular processes contributing to amyloidosis, which can ultimately aid in the development of novel therapeutic strategies.

10/17/2022

The manufacturer plays a crucial role in supporting my research with their extensive expertise and resources.

01/01/2022

This assurance enables me to confidently utilize the SRPK1 protein in my research, knowing that it will consistently deliver reliable and accurate results.

Q&As

Can SRPK1 inhibition be used in combination with other cancer treatments?

Combination therapy with SRPK1 inhibitors and other cancer treatments, such as chemotherapy or immunotherapy, is being explored for enhanced efficacy.

How does SRPK1 influence RNA splicing?

SRPK1 phosphorylates SR proteins, which affects their splicing activity and can lead to the inclusion or exclusion of specific exons in mRNA transcripts.

What other diseases or conditions have been linked to SRPK1?

SRPK1 dysregulation has been implicated in neurodegenerative diseases, cardiovascular disorders, and autoimmune conditions.

Are there any known genetic mutations related to SRPK1 and disease susceptibility?

Some genetic variations in the SRPK1 gene have been associated with increased susceptibility to certain diseases, but further research is needed to establish these connections.

How does SRPK1 play a role in RNA processing disorders?

SRPK1 abnormalities can lead to errors in RNA splicing, contributing to RNA processing disorders, such as spinal muscular atrophy and myotonic dystrophy.