Recombinant Human SNCA, His-tagged
Cat.No. : | SNCA-9160H |
Product Overview : | Recombinant human SNCA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
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Description : | Alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. α-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. in 20 mM Tris-HCl buffer (pH7.5) containing 0.1M NaCl, 1mM MgCl2 |
Molecular Mass : | 14.4 kDa (140aa), confirmed by MALDI-TOF |
Endotoxin : | Less than 0.1 ng/μg (IEU/μg) of recombinant human Alpha Synuclein by the LAL method |
Purity : | More than 95%, as determined by SDS-PAGE |
Stability : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by BCA assay) |
Gene Name : | SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ] |
Official Symbol : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; synuclein alpha-140; non A-beta component of AD amyloid; PARK1; PARK4; MGC110988; |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345 |
Protein Refseq : | NP_000336 |
MIM : | 163890 |
UniProt ID : | P37840 |
Chromosome Location : | 4q21.3-q22 |
Pathway : | Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Parkinsons disease, organism-specific biosystem; |
Function : | Hsp70 protein binding; alpha-tubulin binding; arachidonic acid binding; calcium ion binding; copper ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dynein binding; NOT fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; oxidoreductase activity; NOT phospholipase D inhibitor activity; phosphoprotein binding; protein binding; tau protein binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
SNCA-2055H | Recombinant Human SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
SNCA-02H | Recombinant Human SNCA Protein | +Inquiry |
SNCA-2058H | Recombinant Human SNCA Protein, MYC/DDK-tagged | +Inquiry |
SNCA-01H | Active Recombinant Human SNCA Protein | +Inquiry |
SNCA-2744H | Recombinant Human SNCA protein(11-110 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
SNCA-27339TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27341TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27345TH | Native Human alpha Synuclein | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
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