Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)
Cat.No. : | SNCA-5124H |
Product Overview : | Recombinant human SNCA was expressed in E. coli and purified by using conventional chromatography techniques. |
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Cat. No. : | SNCA-5124H |
Description : | A deletion mutant of alpha-synuclein (amino acids 61-140). Syn61-140 was overexpressed in E. coli and was purified to apparent homogeneity by taking advantage of the thermosolubility of protein and by using conventional column chromatography techniques. Additional amino acid(Met) is attached at the N-terminus. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid In 20mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl. |
Purity : | > 95% by SDS - PAGE |
Sequence : | MEQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
Molecular Mass : | 8.4 kDa (81 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Tag : | Non |
Gene Name : | SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ] |
Official Symbol : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP) |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345 |
Protein Refseq : | NP_000336 |
MIM : | 163890 |
UniProt ID : | P37840 |
Chromosome Location : | 4q21 |
Pathway : | Alzheimer"s disease; Neurodegenerative Disorders; Parkinson"s disease |
Function : | zinc ion binding; tau protein binding; protein binding; phosphoprotein binding; NOT phospholipase D inhibitor activity; NOT fatty acid binding; magnesium ion binding; kinesin binding; identical protein binding; Hsp70 protein binding; histone binding; ferrous iron binding; dynein binding; caspase inhibitor activity; calcium ion binding; arachidonic acid binding; alpha-tubulin binding |
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SNCA-01H | Active Recombinant Human SNCA Protein | +Inquiry |
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◆ Native Protein | ||
SNCA-27342TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27339TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27345TH | Native Human alpha Synuclein | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
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