Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K
Cat.No. : | SNCA-294H |
Product Overview : | Recombinant Humanα-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques (140 aa, 14.4 kDa). |
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Cat. No. : | SNCA-294H |
Description : | α-Synuclein E46K is a mutant form of α-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant (E46K) of α-synuclein causes Parkinson and Lewy Body dementia(DLB). |
Source : | E.coli. |
Formulation : | Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl. |
Molecular Weight : | 14.4 kDa (Real molecular size on SDS-PAGE will be shift up). |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by BCA assay). |
Sequence : | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
Storage : | Store at -20 °C. Avoid freeze/thaw cycles. |
Tag : | Non |
Gene Name : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP). |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345.3 |
Protein Refseq : | NP_000336.1 |
MIM : | 163890 |
UniProt ID : | P37840 |
Chromosome Location : | 4q21 |
Pathway : | Alzheimer"s disease;Neurodegenerative Disorders; Parkinson"s disease. |
Function : | Hsp70 protein binding;alpha-tubulin binding; dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity. |
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◆ Native Protein | ||
SNCA-27341TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27345TH | Native Human alpha Synuclein | +Inquiry |
SNCA-27339TH | Native Human alpha Synuclein | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
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