Recombinant Human Wolf-Hirschhorn Syndrome Candidate 2, T7-tagged

• Cat.No.: WHSC2-3015H
• Product Overview: Recombinant Human WHSC2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 57349 Da(525 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Description: Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.
• Sequences of amino acids: 1-525 aa
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 90%

Gene Information

• Gene Name: WHSC2 Wolf-Hirschhorn syndrome candidate 2 [ Homo sapiens ]
• Synonyms: Wolf-Hirschhorn syndrome candidate 2;NELFA; NELF-A; FLJ10442; FLJ25112; P/OKcl.15; WHSC2; negative elongation factor A; OTTHUMP00000211580
• Gene ID: 7469
• mRNA Refseq: NM_005663
• Protein Refseq: NP_005654
• MIM: 606026
• UniProt ID: Q9H3P2
• Chromosome Location: 4p16.3
• Pathway: Gene Expression; HIV Infection; Transcription