Recombinant Mouse Cd276 protein, His-tagged
Cat.No. : | Cd276-479M |
Product Overview : | Recombinant Mouse Cd276 (Val29-Phe244) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | September 20, 2024 |
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Description : | B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Val29 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 25.4 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Val29-Phe244 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Cd276 |
Official Symbol : | Cd276 |
Synonyms : | CD276; CD276 antigen; B7-H3; B7 homolog 3; costimulatory molecule; B7h3; B7RP-2; AU016588; 6030411F23Rik |
Gene ID : | 102657 |
mRNA Refseq : | NM_133983 |
Protein Refseq : | NP_598744 |
UniProt ID : | Q8VE98 |
Products Types
◆ Recombinant Protein | ||
CD276-599H | Recombinant Human CD276 Protein | +Inquiry |
CD276-600H | Recombinant Human CD276 Protein, Fc-tagged | +Inquiry |
CD276-2631H | Recombinant Human CD276 Protein, His (Fc)-Avi-tagged | +Inquiry |
Cd276-219M | Recombinant Mouse Cd276 Protein, MYC/DDK-tagged | +Inquiry |
CD276-1720H | Recombinant Human CD276 protein, hFc-tagged | +Inquiry |
◆ Lysates | ||
CD276-826RCL | Recombinant Rat CD276 cell lysate | +Inquiry |
CD276-001MCL | Recombinant Mouse CD276 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt has consistently demonstrated high sensitivity and accuracy in detecting and quantifying target molecules, allowing for precise and reliable measurement of analytes in my experimental samples.
Its versatility and reliability make it an excellent choice for research applications, and I highly recommend it to fellow scientists.
The sensitivity and specificity of the CD276 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.
Q&As (5)
Ask a questionCD276 has been associated with autoimmune diseases and certain inflammatory conditions. Exploring its role in these diseases may open avenues for therapeutic interventions.
Research suggests that CD276 expression levels may serve as a diagnostic biomarker for certain cancers. Detection methods, such as immunohistochemistry, are being explored to assess CD276 levels in tumor tissues.
CD276 can modulate the tumor microenvironment by suppressing immune responses, promoting angiogenesis, and supporting tumor cell survival. Understanding these interactions is crucial for developing targeted therapies.
Yes, several clinical trials are underway to evaluate the safety and efficacy of CD276-targeted therapies in different cancer types. These trials aim to assess the impact on patient outcomes and potential side effects.
CD276-targeted therapy focuses on modulating the immune response against cancer cells, whereas traditional treatments like chemotherapy and radiation target rapidly dividing cells, including both healthy and cancerous cells.
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