Recombinant Mouse TLR4 Protein, His (Fc)-Avi-tagged

• Cat.No.: TLR4-9237M
• Product Overview: Recombinant Mouse TLR4 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Tlr4 toll-like receptor 4 [ Mus musculus ]
• Official Symbol: TLR4
• Gene ID: 21898
• mRNA Refseq: NM_021297.2
• Protein Refseq: NP_067272.1
• UniProt ID: Q9QUK6

Reviews

12/29/2020

Precision in every experiment—this product is a game-changer for us.

04/07/2019

Timely delivery is key, and this product arrived on schedule.

08/06/2018

Exceptional customer service—knowledgeable staff guided us through the selection process.

Q&As

How does TLR4 signaling intersect with the nuclear factor-kappa B (NF-κB) pathway?

TLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.

Can you explain the molecular events following TLR4 activation upon ligand binding?

Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.

What is the role of the TLR4 signaling pathway in innate immunity?

The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.

Can you elaborate on the crosstalk between TLR4 and other pattern recognition receptors (PRRs)?

TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.

Can you describe the molecular structure of TLR4 and its functional domains?

TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.