Recombinant Rat Atxn3, His-tagged
Cat.No. : | Atxn3-3689R |
Product Overview : | Ataxin-3 (Atxn3) |
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Description : | gene associated with spinocerebellar ataxia type 3 . |
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 355 |
Purity : | >90% |
Notes : | Small volumes of Atxn3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Atxn3 ataxin 3 [ Rattus norvegicus ] |
Official Symbol : | Atxn3 |
Synonyms : | ATXN3; ataxin 3; ataxin-3; machado-Joseph disease protein 1 homolog; Rsca3; |
Gene ID : | 60331 |
mRNA Refseq : | NM_021702 |
Protein Refseq : | NP_067734 |
Chromosome Location : | 6q32 |
Pathway : | Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem; |
Function : | cysteine-type peptidase activity; molecular_function; omega peptidase activity; peptidase activity; |
Products Types
◆ Recombinant Protein | ||
ATXN3-3036H | Recombinant Human ATXN3 Protein, MYC/DDK-tagged | +Inquiry |
ATXN3-410H | Recombinant Human ATXN3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATXN3-0367H | Recombinant Human ATXN3 Protein (E2-K361), Tag Free | +Inquiry |
ATXN3-0368H | Recombinant Human ATXN3 Protein (E2-K361), His tagged | +Inquiry |
ATXN3-2786H | Recombinant Human ATXN3 protein(11-290 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
ATXN3-52HCL | Recombinant Human ATXN3 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewATXN3 is very catalytic active and shows excellent catalytic performance even at low concentrations.
ATXN3 detection method is sensitive and can detect trace amounts of protein, which is well suited for our study.
Using ATXN3, the reproducibility of my experiments is very good, which facilitates subsequent data analysis and experimental manipulation.
Q&As (6)
Ask a questionThe clinical manifestations of SCA3 include ataxia (especially limb motor coordination disorder), myoclonus, ocular muscle movement abnormalities, extrapyramidal symptoms, dysphagia, language disorder, etc. As the disease progresses, patients have more and more significant difficulties with walking, balance, and other movements.
ATXN3 protein is involved in many important cellular processes, including protein degradation, cell signaling, apoptosis, RNA metabolism, etc. It plays an important role in the regulation of cellular functions.
At present, there is no cure for SCA3, but some adjuvant therapies can be used to improve symptoms. Physical therapy, speech therapy and swallowing function training can improve the quality of life of patients. In addition, there are some studies on protein degradation pathways for abnormal aggregation of ATXN3 protein, but they are still in the experimental stage.
In addition to its association with SCA3, ATXN3 protein may also be associated with some other diseases. For example, studies have shown that ATXN3 protein is related to the occurrence and development of neurodegenerative diseases such as Parkinson's disease and Huntington's disease, but the specific mechanism needs to be further studied and verified.
SCA3 is caused by mutations in the ATXN3 gene that lead to excessive repeat of polyglutamine (PolyQ) sequences in ATXN3 protein. This abnormal expansion will cause abnormal ATXN3 protein folding and aggregation, leading to impaired cell function and eventually triggering SCA3 symptoms.
ATXN3 protein is associated with autodominant genetic disease Spinocerebellar Ataxia Type 3 (SCA3). SCA3 is a neurodegenerative disease characterized by ataxia, extrapyramidal symptoms, and motor neuron dysfunction.
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