Recombinant Rat CALCRL Protein Pre-coupled Magnetic Beads

• Cat.No.: CALCRL-754R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Calcrl calcitonin receptor-like [ Rattus norvegicus ]
• Official Symbol: CALCRL
• Gene ID: 25029
• mRNA Refseq: NM_012717.1
• Protein Refseq: NP_036849.1
• UniProt ID: Q63118

Reviews

05/02/2020

I rely on the product for consistent and reproducible outcomes.

07/25/2019

The product is an indispensable part of my lab routine.

09/19/2018

The timely delivery of the product was a pleasant surprise.

Q&As

What is the chemical structure of CALCRL, and how does it interact with CGRP?

CALCRL is a G-protein-coupled receptor (GPCR). It interacts with CGRP by binding to it, initiating intracellular signaling pathways.

What is the relationship between CALCRL and the CGRP receptor (RAMP1) in mediating CGRP's effects?

CALCRL forms a complex with the receptor activity-modifying protein 1 (RAMP1) to create the functional CGRP receptor, allowing CGRP to exert its biological actions.

What is the primary function of CALCRL in relation to CGRP?

CALCRL mediates the biological effects of CGRP, which include vasodilation, pain modulation, and inflammation regulation.

How does the signaling through CALCRL differ from that through other GPCRs, and what are its downstream signaling pathways?

Signaling through CALCRL is specific to CGRP. Downstream pathways include activation of cyclic AMP (cAMP) and intracellular calcium levels, influencing vascular tone and pain perception.

What are the clinical applications and significance of studying CALCRL in conditions like migraine and chronic pain?

Understanding CALCRL's role in CGRP signaling has led to the development of targeted therapies for migraine and chronic pain, making it a significant area of clinical research.