Recombinant Zebrafish ACTB1

• Cat.No.: ACTB1-8660Z
• Product Overview: Recombinant Zebrafish ACTB1 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: actb1 actin, beta 1 [ Danio rerio (zebrafish) ]
• Official Symbol: ACTB1
• Gene ID: 57934
• mRNA Refseq: NM_131031
• Protein Refseq: NP_571106
• UniProt ID: Q7ZVI7

Reviews

06/27/2020

I felt confident in using the product, knowing it met the highest industry standards.

04/29/2020

I could confidently rely on the product's stability and performance throughout my experiments

02/14/2019

The extensive selection of protein variants allowed for precise experimental design

01/31/2018

The protein product consistently delivered accurate and reproducible results

11/26/2016

I could easily incorporate the product into my existing workflow without any issues.

Q&As

What is the predicted function of ACTB1?

ACTB1 is predicted to function as a structural constituent of the postsynaptic actin cytoskeleton.

What are the functions of the actin cytoskeleton in which ACTB1 is involved?

 The actin cytoskeleton, with the involvement of ACTB1, is responsible for various cellular processes such as cell shape maintenance, cell movement, intracellular transport, and cell division.

What genetic disorders are implicated by mutations in ACTB1?

Mutations in ACTB1 have been implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20.

What is the predicted activity of ACTB1?

ACTB1 is predicted to be active in actin filament formation.

What is the function of ACTB1 in the actin cytoskeleton?

ACTB1 provides structural support and stability to the actin cytoskeleton.

How does ACTB1 contribute to cell migration?

ACTB1, as a component of the actin cytoskeleton, provides the necessary structure and dynamics for cell migration by facilitating the formation and remodeling of actin filaments at the leading edge of migrating cells.

How does ACTB1 contribute to cellular transport processes?

ACTB1, as a key component of the actin cytoskeleton, is involved in facilitating intracellular transport by providing tracks for motor proteins to move along and by participating in the organization and dynamics of cellular transport pathways.

What is the significance of ACTB1's localization in dense bodies and focal adhesions?

The localization of ACTB1 in dense bodies and focal adhesions suggests its involvement in cell structure and adhesion processes.

What is the role of ACTB1 in cellular processes?

ACTB1 is involved in various cellular processes, such as cell migration, cell division, and intracellular transport.

What is the orthologous gene of ACTB1 in humans?

ACTB1 is orthologous to the human gene ACTB (actin beta), which shares similarity and is involved in cytoskeletal organization and cellular processes.

What is the significance of ACTB1 expression in the eye?

ACTB1 expression in the eye suggests its involvement in maintaining the structural integrity and function of ocular tissues, such as the lens and the retina.

In which cellular components is ACTB1 predicted to be located?

ACTB1 is predicted to be located in several cellular components, including the actin cytoskeleton, dense body, and focal adhesion.

How does ACTB1 influence hematopoietic cells?

ACTB1 likely plays a role in the cytoskeletal organization and cellular processes of hematopoietic cells, which are responsible for the production and maturation of blood cells.

What is the potential impact of ACTB1 dysregulation in liver?

Dysregulation of ACTB1 expression in the liver, such as elevated levels observed in certain cancers, may contribute to liver tumorigenesis and affect cellular processes related to liver function and metabolism.

In which structures or tissues is ACTB1 expressed?

ACTB1 is expressed in several structures and tissues, including the eye, hematopoietic cells, liver, male organism, and pleuroperitoneal region.

Are there any other known implications of ACTB1 mutations?

In addition to Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20, mutations in ACTB1 have also been associated with other conditions such as dilated cardiomyopathy and intellectual disability.

What is the role of ACTB1 in cellular adhesion?

ACTB1 plays a role in focal adhesion, which is important for cell adhesion to the extracellular matrix and for transmitting mechanical signals between the cell and its environment.

Can you provide more details about ACTB1's role in pleuroperitoneal region?

The involvement of ACTB1 in the pleuroperitoneal region suggests its potential role in the development and maintenance of tissues in this region, which includes the membranes surrounding the lungs and the peritoneal cavity.

How does ACTB1 contribute to the pathogenesis of Baraitser-Winter syndrome?

Mutations in ACTB1 can disrupt the normal function of the actin cytoskeleton, leading to the characteristic features and brain abnormalities observed in Baraitser-Winter syndrome.

How does ACTB1 contribute to DNA repair?

 ACTB1 is involved in DNA repair processes through its association with actin-related proteins, which participate in chromatin remodeling and facilitate DNA repair activities.