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APCS

  • Official Full Name

    amyloid P component, serum

  • Overview

    The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
  • Synonyms

    APCS; amyloid P component, serum; SAP; PTX2; MGC88159; serum amyloid P-component; pentaxin-related; OTTHUMP00000024355; 9.5S alpha-1-glycoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Transfected Stable Cell Lines
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Serum
  • Mammalian cells
  • Mouse Serum
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APCS-9734H Recombinant Human APCS, GST-tagged E.coli GST 20-223a.a.
Human APCS-72H Recombinant Human Amyloid P Component, Serum, T7-tagged E.coli T7
Human APCS-8600H Recombinant Human APCS protein, His-tagged HEK293 His His20-Val223
Human APCS-674H Recombinant Human APCS protein, GST-tagged Wheat Germ GST
Human APCS-1269HCL Recombinant Human APCS cell lysate Human Cell N/A
Human APCS-31189TH Native Human APCS N/A 204 amino acids
Human APCS-353H Recombinant Human APCS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human APCS-341H Recombinant Human APCS Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human APCS-811H Recombinant Human APCS Protein HEK293 223
Human APCS-8258H Native Human Serum Amyloid P Human Serum N/A
Human APCS-4244H Recombinant Human APCS Protein (Met1-Val223), C-His tagged Mammalian cells C-His Met1-Val223
Human APCS-353H-B Recombinant Human APCS Protein Pre-coupled Magnetic Beads HEK293
Human APCS-0304H Recombinant Human APCS Protein (Leu23-Val223), N-GST-tagged E.coli N-GST Leu23-Val223
Human APCS-2311H Recombinant Human APCS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APCS-5846H Recombinant Human APCS Protein (His20-Val223), C-His tagged Mammalian cells C-His His20-Val223
Human APCS-2526H Recombinant Human APCS protein, GST-tagged E.coli GST 1-223aa
Human APCS-851HFL Recombinant Full Length Human APCS Protein, C-Flag-tagged Mammalian cells Flag
Mouse Apcs-585M Active Recombinant Mouse Apcs protein(Met1-Asp224), His-tagged HEK293 C-His Met1-Asp224
Mouse APCS-3089MCL Recombinant Mouse APCS cell lysate Human Cell N/A
Mouse Apcs-6768M Recombinant Mouse Apcs Protein (Gln21-Asp224), C-His tagged Mammalian cells C-His Gln21-Asp224
Mouse Apcs-4893M Mouse Apcs Reference serum Mouse Serum N/A
Mouse Apcs-1261M Recombinant Mouse Apcs Protein, His-tagged E.coli N-His Cys20-Asp224
Mouse APCS-728M Recombinant Mouse APCS Protein, His-tagged HEK293 His 21-224 aa
Mouse Apcs-57M Mouse SAP Reference Standard N/A
Mouse Apcs-1658M Recombinant Mouse Apcs Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Apcs-6863R Recombinant Rat Apcs protein(Met1-Ser228), His-tagged HEK293 C-His Met1-Ser228
Rat Apcs-7095R Recombinant Rat Apcs protein, His-tagged E.coli His Thr22~Met222 (Accession # P23680)
Rat APCS-1761RCL Recombinant Rat APCS cell lysate Human Cell N/A
Rat Apcs-90R Rat SAP Reference Standard N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APCS Related Articles

APCS involved in several pathways and played different roles in them. We selected most pathways APCS participated on our site, such as Amyloid formation, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyloid formationHIST2H3C;LTF;CST3;HIST3H2BB;HIST4H4;RHBDL1;NAT8B;TGFBI;CEACAM21
Metabolism of proteinsGALNT6;PPP6R3;B3GNT3;GRPEL2;TBCD;MUC4;SERP1;UBA2;CTSH

APCS has several biochemical functions, for example, calcium ion binding, carbohydrate binding, complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APCS itself. We selected most functions APCS had, and list some proteins which have the same functions with APCS. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingFAT1A;NCALDA;GSNA;PCDH2AA3;PCDH1G31;RHOT1B;IHH;MYL2;THBS2
carbohydrate bindingCHI3L1;CHI3L2;POC1BL;ACAN;GALNTL6;CLEC7A;GFPT2;GALNT2;CLEC4F
complement component C1q bindingCD93;C1QBP;C4A;PTX3;CALR;APCS;CRP
unfolded protein bindingCLPX;HSPA8;APCS;CDC37L1;HSPA9;SSUH2.2;PFDN6;CLPXA;ST13
virion bindingPPIA;HSP90B1;CD209;PTX3;HIPK2;PVRL1;CLEC4M;TSG101;APCS

APCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APCS here. Most of them are supplied by our site. Hope this information will be useful for your research of APCS.

GOT2; GK; GRB2; HES1; COPS5; d-mannose

Veninga, H; Borg, EGF; et al. Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses. EUROPEAN JOURNAL OF IMMUNOLOGY 45:747-757(2015).
Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
Is there a time limit for therapy? 10/27/2022

The duration of use of therapy depends on the type of disease and treatment regimen, and needs to be carried out under the guidance of a professional physician.

What are the advantages and disadvantages of compared with other treatments? 09/17/2022

The advantages and disadvantages of s versus other treatments need to be evaluated in the context of the specific disease and treatment regimen.

Can s achieve precision medicine? 05/20/2022

The specificity and specificity of s allow them to be used in precision medicine to achieve personalized treatment.

Does the stability of affect its clinical application? 04/08/2022

The stability of the is one of the important factors for its clinical application, and poor stability of the protein may lead to adverse reactions in patients or reduce the therapeutic effect.

Does the have immunogenicity? 04/06/2022

Recombinant proteins, as exogenous proteins, may cause a response from the immune system, but there are already several techniques used to reduce their immunogenicity.

Can s be used in vaccine preparation? 02/20/2022

Recombinant proteins can be used in vaccine preparation, and there are already several vaccines based on s on the market.

Does the work better than traditional drugs? 04/16/2021

The efficacy of s and traditional drugs depends on the type of disease and individual differences, and needs to be selected on a case-by-case basis.

Can s be used to treat what diseases? 03/23/2021

Recombinant proteins can be used to treat a variety of diseases, such as immune deficiency diseases, tumors, cardiovascular diseases, etc.

Can achieve therapeutic effect through oral administration? 01/21/2021

Recombinant proteins usually need to be administered intravenously, but there are also some oral s that are currently being studied.

Is the preparation of capable of large-scale production? 11/30/2020

With the advancement of technology, the preparation of s has also been continuously improved, and large-scale production has become possible.

Is there any potential risk in the application of s? 11/02/2020

Any medical technology and drug treatment has a certain risk, is no exception, need to be reasonable application under the guidance of professional doctors.

Is the preparation of s limited by policies and regulations? 10/19/2020

The preparation of s is subject to compliance with relevant policies and regulations, particularly with regard to biosafety.

What are the basic principles of therapy? 08/06/2020

Recombinant protein therapy should follow the basic principles of individuality, pertinence, safety and effectiveness.

Have the pharmacokinetics and pharmacodynamics of s been clearly understood? 06/09/2020

The pharmacokinetics and pharmacodynamics of s have been clearly understood, but they still need to be explored and perfected in clinical practice.

Is the production cost of high? 03/15/2020

The production cost of is relatively high, but because of its therapeutic effect and broad application prospects, it has become an important field in the pharmaceutical industry.

Does the application of s require individual adjustment? 02/23/2020

The application of s needs to be adjusted individually according to the specific situation of the patient in order to achieve the optimal therapeutic effect.

Can s be used in the treatment of neurological diseases? 02/06/2020

Recombinant proteins have been used in the treatment of various neurological diseases, such as multiple sclerosis and Parkinson's disease.

What is the application prospect of ? 09/27/2019

As a new drug therapy technology, has broad application prospects, and more s may be used in the future.

Is the easily broken down in the body? 04/13/2019

Recombinant proteins are subject to various metabolic and decomposition influences in the body, and different proteins will have different stability and half-lives.

Are clinical trials of s strictly regulated? 02/09/2019

Clinical trials of s are subject to strict compliance with relevant ethical and regulatory requirements and are subject to regulatory approval and supervision.

Customer Reviews (4)

Write a review
Reviews
05/22/2022

    Short half-life and high clearance.

    09/17/2021

      APCS produced by them has low preparation cost and high cost performance.

      08/17/2021

        Stability of APCS is very good, and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.

        08/03/2019

          Production process is very much in line with the principle of green production.

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