Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
CD86 involved in several pathways and played different roles in them. We selected most pathways CD86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CD86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD86 itself. We selected most functions CD86 had, and list some proteins which have the same functions with CD86. You can find most of the proteins on our site.
CD86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD86 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD86.
CTLA4; CD80; ECE2; PARP1
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Wang, L; Sun, XG; et al. Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38(+) Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis. DIGESTIVE DISEASES AND SCIENCES 60:405-413(2015).
Are there any ongoing clinical trials involving CD86 inhibitors?
02/18/2023
Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.
How does CD86 contribute to transplant medicine?
02/03/2021
In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.
How does CD86 influence the balance between Th1 and Th2 immune responses?
08/26/2019
CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.
Can CD86 be used as a prognostic marker in certain diseases?
12/29/2018
There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.
How does CD86 influence the development of regulatory T cells (Tregs)?
10/02/2016
CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.
With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
05/30/2021
Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
12/08/2017
The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.