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BAAT

  • Official Full Name

    bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

  • Overview

    The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    BAAT; bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid Coenzyme A: amino acid N acyltransferase (glycine N choloyltransferase); bile acid-CoA:amino acid N-acyltransferase; BAT; FLJ20300; BACAT; Bile acid CoA:amino acid N acyltransferase; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase; Bile acid Coenzyme A: amino acid N acyltransferase; Glycine N choloyltransferase; Long chain fatty acyl CoA hydrolase; MGC104432; OTTHUMP00000021802; long-chain fatty-acyl-CoA hydrolase; bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BAAT-042H Recombinant Human BAAT protein, GST-tagged Wheat Germ GST
Human BAAT-10119H Recombinant Human BAAT, GST-tagged E.coli GST 1-418a.a.
Human BAAT-8533HCL Recombinant Human BAAT 293 Cell Lysate HEK293 N/A
Human BAAT-1425H Recombinant Human BAAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse BAAT-2262M Recombinant Mouse BAAT Protein Mammalian Cell His
Mouse BAAT-944M Recombinant Mouse BAAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Baat-686M Recombinant Mouse Baat Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BAAT-944M-B Recombinant Mouse BAAT Protein Pre-coupled Magnetic Beads HEK293
Rat BAAT-927R Recombinant Rat BAAT Protein Mammalian Cell His
Rat BAAT-585R-B Recombinant Rat BAAT Protein Pre-coupled Magnetic Beads HEK293
Rat BAAT-585R Recombinant Rat BAAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BAAT involved in several pathways and played different roles in them. We selected most pathways BAAT participated on our site, such as Primary bile acid biosynthesis, Taurine and hypotaurine metabolism, Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Primary bile acid biosynthesisACOX2;CYP46A1.1;CYP39A1;CH25HL1.2;BRSK2;CH25H;CYP46A1.2;BAAT;SLC27A5
Taurine and hypotaurine metabolismADOB;CDO1;GAD1B;GGT7;ADO;GGT5;GGT1A;BAAT;GGT1
Biosynthesis of unsaturated fatty acidsHADHAB;ACOX3;ACAA1;HSD17B12B;PTPLAD1;Scd2;BAAT;ACOT1;FADS1
Metabolic pathwaysTPI1A;GALNT7;UGT2A3;UXS1;PON1;BCO1;NMNAT1;ALDOCA;MTHFD1L
PeroxisomePEX10;ACSL1A;FAR2;ACAA1A;MPV17L2;ABCD3;CAT;HAO2;ABCD2
Bile secretionSLC10A1;ATP1B4;CYP7A1;Abcb1b;Slc4a2;AQP4;ABCG2;KCNN2;ATP1B1

BAAT has several biochemical functions, for example, N-acyltransferase activity, carboxylic ester hydrolase activity, glycine N-choloyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BAAT itself. We selected most functions BAAT had, and list some proteins which have the same functions with BAAT. You can find most of the proteins on our site.

Function Related Protein
N-acyltransferase activityCML5;Acnat1;LPCAT3;HHAT;ACNAT2;MBOAT4;HRASLS5;BAAT;NAT14
carboxylic ester hydrolase activityCES1D;AADACL2;LIPCA;ABHD11;CES3A;ACOT7;Aadacl3;LYPLA2;ACOT10
glycine N-choloyltransferase activity
long-chain acyl-CoA hydrolase activity
medium-chain acyl-CoA hydrolase activityBAAT;ACOT8
palmitoyl-CoA hydrolase activityGNPAT;ACOT2;THEM4;THEM5;ACOT8;PPT1;ACOT1;BAAT;ACOT5
protein bindingGABRG2;BAHD1;SCRN2;FLI1;UHRF2;ACP1;KCNA1;RARA;SH3BP1
receptor bindingNUDT19;BAAT;IDUA;SCP2;LAMA1;SMARCD1;SMARCD3;TAC3;Icosl
very long chain acyl-CoA hydrolase activity

BAAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAAT here. Most of them are supplied by our site. Hope this information will be useful for your research of BAAT.

GOLGA8F; GOLGA8DP; AURKA; BUB1; BCL10; ERBB2; RB1; ODC1; SRC; MCC; APC; CTNNA1; MLH1; PTPRJ; SMAD4; PDGFRL

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