casp8
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  • Official Full Name
  • caspase 8, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease
Cat.#:Casp8-1645MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 8
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Cat.#:CASP8-147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 Protein, His-tagged
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Cat.#:CASP8-26606THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8
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Cat.#:CASP8-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8, His-tagged
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Cat.#:CASP8-558HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP8
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Cat.#:CASP8-7828HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 protein, His & T7-tagged
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Cat.#:CASP8-7829HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 protein, His-tagged
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Cat.#:CASP8-2756MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP8 Protein
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Cat.#:Casp8-7830MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp8 protein, His & T7-tagged
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Cat.#:Casp8-7831MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp8 protein, His & T7-tagged
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Cat.#:CASP8-1146RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CASP8 Protein
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Cat.#:Casp8-7832RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp8 protein, His & T7-tagged
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Cat.#:CASP8-6161CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CASP8
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Cat.#:CASP8-9059ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP8
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Cat.#:CASP8-7827CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CASP8 protein, His-tagged
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Cat.#:CASP8-404HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 8, Apoptosis-Related Cysteine Peptidase
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Cat.#:CASP8-7829HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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Cat.#:CASP8-7830HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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Cat.#:CASP8-7831HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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CASP8 Related Articles

Shaw, BE; Lee, F; et al. Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation. BONE MARROW TRANSPLANTATION 50:237-243(2015).
Hu, Y; Liu, HX; et al. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. BIOCHEMICAL PHARMACOLOGY 85:1007-1017(2013).