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CDKN2A

  • Official Full Name

    cyclin-dependent kinase inhibitor 2A

  • Overview

    The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene(isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.
  • Synonyms

    CDKN2A; cyclin-dependent kinase inhibitor 2A; Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a); cyclin-dependent kinase inhibitor 2A, isoform 3; CDK4I; p16-INK4; p16-INK4a; mitochondrial smARF; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • 13
  • TAT
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDKN2A-117H Recombinant Human CDKN2A Protein, 13-residue TAT-tagged E.coli 13-TAT
Human CDKN2A-10H Recombinant Human CDKN2A protein E.coli N/A 156
Human CDKN2A-655H Recombinant Human CDKN2A protein E.coli N/A 167
Human CDKN2A-7704H Recombinant Human CDKN2A protein, His & T7-tagged E.coli His/T7 Ser8~Asp156 (Accession # P42771)
Human CDKN2A-1060H Recombinant Human CDKN2A Protein, GST-Tagged Wheat Germ GST
Human CDKN2A-7616HCL Recombinant Human CDKN2A 293 Cell Lysate HEK293 N/A
Human CDKN2A-3720H Recombinant Human CDKN2A protein, GST-tagged E.coli GST 55-156 aa
Human CDKN2A-1335H Recombinant Human CDKN2A Protein (Met1-Asp156), N-His tagged E.coli N-His Met1-Asp156
Human CDKN2A-569H-B Recombinant Human CDKN2A Protein Pre-coupled Magnetic Beads HEK293
Human CDKN2A-3227HF Recombinant Full Length Human CDKN2A Protein, GST-tagged In Vitro Cell Free System GST 105 amino acids
Human CDKN2A-0979H Recombinant Human CDKN2A Protein (Met1-Asp156), N-His tagged Mammalian cells N-His Met1-Asp156
Human CDKN2A-423HFL Recombinant Full Length Human CDKN2A Protein, C-Flag-tagged Mammalian cells Flag
Human CDKN2A-569H Recombinant Human CDKN2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cdkn2a-7705M Recombinant Mouse Cdkn2a protein, His & T7-tagged E.coli His/T7 Ser3~Thr154 (Accession # P51480)
Mouse CDKN2A-3223M Recombinant Mouse CDKN2A Protein Mammalian Cell His
Mouse CDKN2A-1537M-B Recombinant Mouse CDKN2A Protein Pre-coupled Magnetic Beads HEK293
Mouse CDKN2A-1537M Recombinant Mouse CDKN2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CDKN2A-1313R Recombinant Rat CDKN2A Protein Mammalian Cell His
Rat Cdkn2a-7706R Recombinant Rat Cdkn2a protein, His & T7-tagged E.coli His/T7 Ser3~Pro155 (Accession # Q9R0Z3)
Rat CDKN2A-971R Recombinant Rat CDKN2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CDKN2A-971R-B Recombinant Rat CDKN2A Protein Pre-coupled Magnetic Beads HEK293
Chicken CDKN2A-6004C Recombinant Chicken CDKN2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDKN2A Related Articles
  • CDKN2A Related Research Area

CDKN2A involved in several pathways and played different roles in them. We selected most pathways CDKN2A participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisTNFRSF10A;IL3RA;CASP6;IL1R1;DFFA;GZME;IRF1B;IKBKB;CASP6L2
Apoptosis Modulation and SignalingPTPN13;DAXX;SEPT4;BIK;HRK;CDKN2A;HN1;CRADD;BLK
Bladder cancerMMP1;RPS6KA5;MAPK1;VEGFA;CCND1;FGFR3;ERBB2;MAP2K1;RASSF1
Cell CycleCDC6;SMC2;SMC1A;GINS4;CHEK1;WEE1;NEK2;TERF2IP;CEP63
Cell Cycle, MitoticKNTC1;ENSA;CDK7;CEP290;NEK9;CDK4;DHFR;POLD3;TOP2A
Cellular SenescenceRBBP4;HIST1H1C;KAT5;H1F0;TERF2IP;HIST1H1E;ERF;HMGA1-RS1;RBB4L
Cellular responses to stressPOT1;RRAGA;HIST1H1B;CBX4;HSPA13;CBX8A;EED;AMBRA1;MAP1LC3B

CDKN2A has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NF-kappaB binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2A itself. We selected most functions CDKN2A had, and list some proteins which have the same functions with CDKN2A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF574;SNAPC3;ZNF672;ZFP90;GTF2IRD2;HOXA5;ZNF557;POU2F1B;BLZF1
MDM2/MDM4 family protein bindingTRP53;CDK5RAP3;PPARA;RFWD3;CDKN2A;CAV1;PSME3
NF-kappaB bindingHDAC2;FAF1;NFKBIA;CDK5RAP3;NPM1;PSMA6;HIF1AN;GSK3B;HSPA6
cyclin-dependent protein serine/threonine kinase inhibitor activityKAT2B;CDKN2B;CDKN1BA;CDKN2D;INCA1;CDKN1D;Casp3;CDKN1A;CDKN2C
p53 bindingEHMT1;DUSP26;ZFP385C;TRIM24;BRD4;SMYD2;HTT;PTTG1IP;TP53BP1
poly(A) RNA bindingSURF6;MACF1;TOP3B;CDK11B;GNL3L;C1orf35;RRP1;MYO18A;HNRNPDL
protein bindingTUBGCP4;AZI2;LUM;HNRNPC;CDH5;BCL7B;FAM189B;TRA2B;PSMB1
protein kinase bindingELP2;XBP1;CCNL1;NEK9;CDK5R1;PRKCZ;PIH1D1;CALM1;MAG
transcription factor bindingKDM1A;NAAA;ENPP2;DIP2B;HYAL1;PRICKLE1;RARA;RORA;GATA6
ubiquitin-protein transferase inhibitor activityGLMN;CDKN2A

CDKN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2A.

CDK4; CDK6

Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).
Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
  • Q&As
  • Reviews

Q&As (5)

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Is CDKN2A testing common in cancer diagnostics? 10/14/2022

Yes, CDKN2A testing is often included in genetic screenings for individuals with a family history of cancer to assess their risk.

Can CDKN2A testing be used for early cancer detection? 04/04/2022

Yes, CDKN2A testing is being investigated as a potential tool for early cancer detection, especially in high-risk individuals.

In which types of cancer is CDKN2A most commonly implicated? 07/07/2021

CDKN2A mutations are frequently found in melanoma, pancreatic cancer, and certain types of familial cancers.

How can knowledge of CDKN2A status influence cancer treatment decisions? 03/02/2020

Understanding CDKN2A status can guide treatment choices, as certain therapies may be more or less effective based on the presence or absence of functional CDKN2A.

Are there any known side effects associated with CDKN2A-targeted therapies? 06/13/2018

The field is still evolving, but as with many targeted therapies, potential side effects are being monitored, and their impact is being studied.

Customer Reviews (3)

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Reviews
05/12/2022

    As a researcher utilizing the CDKN2A protein in my trials, I have experienced notable advantages that contribute to the efficiency and success of my research.

    11/29/2019

      The CDKN2A protein offers exceptional quality.

      10/02/2016

        The manufacturer's responsive and knowledgeable support team is always available to answer my queries or provide guidance, ensuring that I can proceed with my research smoothly and without delays.

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