CDKN2A
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Official Full Name
cyclin-dependent kinase inhibitor 2A
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Overview
The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene(isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control. -
Synonyms
CDKN2A; cyclin-dependent kinase inhibitor 2A; Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a); cyclin-dependent kinase inhibitor 2A, isoform 3; CDK4I; p16-INK4; p16-INK4a; mitochondrial smARF; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
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- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- 13
- TAT
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CDKN2A Related Articles
- CDKN2A Related Research Area
CDKN2A involved in several pathways and played different roles in them. We selected most pathways CDKN2A participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | TNFRSF10A;IL3RA;CASP6;IL1R1;DFFA;GZME;IRF1B;IKBKB;CASP6L2 |
Apoptosis Modulation and Signaling | PTPN13;DAXX;SEPT4;BIK;HRK;CDKN2A;HN1;CRADD;BLK |
Bladder cancer | MMP1;RPS6KA5;MAPK1;VEGFA;CCND1;FGFR3;ERBB2;MAP2K1;RASSF1 |
Cell Cycle | CDC6;SMC2;SMC1A;GINS4;CHEK1;WEE1;NEK2;TERF2IP;CEP63 |
Cell Cycle, Mitotic | KNTC1;ENSA;CDK7;CEP290;NEK9;CDK4;DHFR;POLD3;TOP2A |
Cellular Senescence | RBBP4;HIST1H1C;KAT5;H1F0;TERF2IP;HIST1H1E;ERF;HMGA1-RS1;RBB4L |
Cellular responses to stress | POT1;RRAGA;HIST1H1B;CBX4;HSPA13;CBX8A;EED;AMBRA1;MAP1LC3B |
CDKN2A has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NF-kappaB binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2A itself. We selected most functions CDKN2A had, and list some proteins which have the same functions with CDKN2A. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF574;SNAPC3;ZNF672;ZFP90;GTF2IRD2;HOXA5;ZNF557;POU2F1B;BLZF1 |
MDM2/MDM4 family protein binding | TRP53;CDK5RAP3;PPARA;RFWD3;CDKN2A;CAV1;PSME3 |
NF-kappaB binding | HDAC2;FAF1;NFKBIA;CDK5RAP3;NPM1;PSMA6;HIF1AN;GSK3B;HSPA6 |
cyclin-dependent protein serine/threonine kinase inhibitor activity | KAT2B;CDKN2B;CDKN1BA;CDKN2D;INCA1;CDKN1D;Casp3;CDKN1A;CDKN2C |
p53 binding | EHMT1;DUSP26;ZFP385C;TRIM24;BRD4;SMYD2;HTT;PTTG1IP;TP53BP1 |
poly(A) RNA binding | SURF6;MACF1;TOP3B;CDK11B;GNL3L;C1orf35;RRP1;MYO18A;HNRNPDL |
protein binding | TUBGCP4;AZI2;LUM;HNRNPC;CDH5;BCL7B;FAM189B;TRA2B;PSMB1 |
protein kinase binding | ELP2;XBP1;CCNL1;NEK9;CDK5R1;PRKCZ;PIH1D1;CALM1;MAG |
transcription factor binding | KDM1A;NAAA;ENPP2;DIP2B;HYAL1;PRICKLE1;RARA;RORA;GATA6 |
ubiquitin-protein transferase inhibitor activity | GLMN;CDKN2A |
CDKN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2A.
CDK4; CDK6
- Q&As
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Q&As (5)
Ask a questionYes, CDKN2A testing is often included in genetic screenings for individuals with a family history of cancer to assess their risk.
Yes, CDKN2A testing is being investigated as a potential tool for early cancer detection, especially in high-risk individuals.
CDKN2A mutations are frequently found in melanoma, pancreatic cancer, and certain types of familial cancers.
Understanding CDKN2A status can guide treatment choices, as certain therapies may be more or less effective based on the presence or absence of functional CDKN2A.
The field is still evolving, but as with many targeted therapies, potential side effects are being monitored, and their impact is being studied.
Customer Reviews (3)
Write a reviewAs a researcher utilizing the CDKN2A protein in my trials, I have experienced notable advantages that contribute to the efficiency and success of my research.
The CDKN2A protein offers exceptional quality.
The manufacturer's responsive and knowledgeable support team is always available to answer my queries or provide guidance, ensuring that I can proceed with my research smoothly and without delays.
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