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CLPP

  • Official Full Name

    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog

  • Overview

    The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.
  • Synonyms

    CLPP; ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli); ClpP (caseinolytic protease, ATP dependent, proteolytic subunit, E. coli) homolog , ClpP caseinolytic protease, ATP dependent, proteolytic subunit homolog (E. coli);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Clostridium Botulinum
  • E.coli
  • Human
  • Mouse
  • Staphylococcus
  • Streptomyces coelicolor A3(2)
  • Zebrafish
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|SUMO
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLPP-694H Recombinant Human caseinolytic mitochondrial matrix peptidase proteolytic subunit, His-tagged E.coli His
Human CLPP-11343H Recombinant Human CLPP, GST-tagged E.coli GST 1-277a.a.
Human CLPP-1679H Recombinant Human Clpp Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E.coli) Human N/A
Human CLPP-1512H Recombinant Human CLPP Protein, GST-tagged Wheat Germ GST
Human CLPP-3538H Recombinant Human CLPP, His-tagged Human His
Human CLPP-7434HCL Recombinant Human CLPP 293 Cell Lysate HEK293 N/A
Human CLPP-3562H Recombinant Human CLPP protein, His-tagged E.coli His 1-277 aa
Human CLPP-1887HF Recombinant Full Length Human CLPP Protein, GST-tagged In Vitro Cell Free System GST 277 amino acids
Mouse CLPP-3599M Recombinant Mouse CLPP Protein Mammalian Cell His
Mouse Clpp-2197M Recombinant Mouse Clpp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CLPP-1766M Recombinant Mouse CLPP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLPP-1766M-B Recombinant Mouse CLPP Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis CLPP-0097B Recombinant Bacillus subtilis CLPP protein, His-tagged E. coli or Yeast His
Clostridium Botulinum CLPP-1971C Recombinant Clostridium Botulinum CLPP Protein (1-194 aa), His-SUMO-tagged E.coli His/SUMO 1-194 aa
E.coli CLPP-1032E Recombinant Escherichia coli (strain UTI89/UPEC) clpP protein (ATP-dependent Clp protease proteolytic subunit), His/Myc-tagged E.coli His/Myc 193
Staphylococcus CLPP-0016S Recombinant Staphylococcus aureus subsp. aureus NCTC 8325 CLPP protein, His-tagged E. coli or Yeast His
Staphylococcus CLPP-3272S Recombinant Staphylococcus epidermidis ATCC 12228 CLPP protein, His-tagged E. coli or Yeast His
Streptomyces coelicolor A3(2) CLPP-937S Recombinant Streptomyces coelicolor A3(2) CLPP protein, His-tagged E. coli or Yeast His
Zebrafish CLPP-2847Z Recombinant Zebrafish CLPP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLPP Related Articles

CLPP involved in several pathways and played different roles in them. We selected most pathways CLPP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLPP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CLPP has several biochemical functions, for example, identical protein binding, peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLPP itself. We selected most functions CLPP had, and list some proteins which have the same functions with CLPP. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingMYOM1;LRRK1;SLC22A1;FADD;SNCAIP;CORO1B;LRRK2;ETNPPL;DRD2
peptidase activityCTSSA;PLAUB;CAPN8;NPSN;ADAMTS4;MCPT8;PRSS42;CAPN1A;CLPP
protein bindingUBTD1;MID2;HPX;PACSIN2;DNASE1;EPM2AIP1;PPIC;CDK2;PTPN18
serine-type endopeptidase activityPRSS33;HTRA2;LTF;KLK13;PRSS54;MASP2;PRSS7;FURIN;F2

CLPP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLPP here. Most of them are supplied by our site. Hope this information will be useful for your research of CLPP.

SAP18; GH1; HLA-B; C20orf24; NDUFA4; IDH3B; CS; PMPCB; MTRF1; CLPX; CDS2; MT-ND1; MT-ATP8; FDX1; COX5B; ACADM; COX6A1; ALAS1; COX7C; COX5A

Zhou, MX; Zhu, F; et al. Gap1 functions as a molecular chaperone to stabilize its interactive partner Gap3 during biogenesis of serine-rich repeat bacterial adhesin. MOLECULAR MICROBIOLOGY 83:866-878(2012).
Ito, J; Nagayasu, Y; et al. ApoA-I enhances generation of HDL-like lipoproteins through interaction between ABCA1 and phospholipase C gamma in rat astrocytes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1811:1062-1069(2011).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any potential therapeutic approaches targeting CLPP? 08/06/2022

Targeting CLPP therapeutically could offer potential in diseases related to mitochondrial dysfunction and aging.

How is the activity of CLPP regulated within the cell? 08/05/2020

CLPP activity is tightly regulated to ensure balanced protein turnover in mitochondria.

In which conditions is CLPP dysregulation observed, and what are its implications? 07/01/2020

Dysregulation of CLPP is linked to various diseases, including mitochondrial disorders.

How does CLPP contribute to mitochondrial protein quality control? 12/21/2019

It helps in degrading misfolded or damaged proteins, maintaining mitochondrial function.

What role does CLPP play in mitochondrial function and health? 07/27/2018

Proper functioning of CLPP is vital for mitochondrial health and energy production.

What is the significance of CLPP in aging and longevity? 07/26/2018

CLPP levels and activity are associated with aging, influencing cellular senescence and longevity.

What is the main function of CLPP in cellular processes? 05/13/2018

CLPP plays a crucial role in mitochondrial protein degradation and quality control.

Customer Reviews (3)

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Reviews
05/03/2022

    Very high purity level.

    11/15/2019

      Worked excellently in experiments.

      08/05/2018

        Product was well packaged.

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