CSF1R
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Official Full Name
colony stimulating factor 1 receptor
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Overview
Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of thi -
Synonyms
CSF1R; colony stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; c-fms; CSF-1-R; CSF-1 receptor; proto-oncogene fms; proto-oncogene c-Fms; Fms; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359; CSFR; FIM2; HDLS;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Canine
- Cat
- Cynomolgus
- Cynomolgus monkey
- Human
- Human
- Mouse
- Rabbit
- Rat
- Rhesus
- Baculovirus-Insect Cells
- CHO cells
- E.coli
- HEK293
- HEK293T
- Human Cell
- Insect Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- 6×His
- Fc
- His
- mFc
- Myc
- DDK
- DDK|His
- Fc Chimera
- Avi
- Fc|His
- Flag
- GST
- hFc
- His (Fc)
- His(C
- ter)
- His|Avi
- His|GST
- His|HIgG
- His|SUMO
- HlgG1 Fc
- human|IgG1|Fc
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- CSF1R Related Articles
- CSF1R Related Research Area
CSF1R involved in several pathways and played different roles in them. We selected most pathways CSF1R participated on our site, such as C-MYB transcription factor network, Cytokine-cytokine receptor interaction, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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C-MYB transcription factor network | ADORA2B;CDK6;CLTA;CREBBP;MYC;SLC25A3;PRTN3;CEBPA;SKI |
Cytokine-cytokine receptor interaction | PRLR;CCR9A;CCL27;TNFRSF10A;FLT3;ACVR1B;PRL2;NT5C3;IFNAR2 |
Endocytosis | IST1;SNX3;TFRC;ARF3A;EPS15;ACAP3;CAV2;RAB22A;KIF5AA |
Hematopoietic cell lineage | CD2;KIT;CD1d1;CD37;HLA-DRB4;Itga10&Itgb1;Fcer2a;IL11RA2;CD3E |
Integrins in angiogenesis | MFGE8;EDIL3;CSF1;CSF1R;ANGPTL3 |
Osteoclast differentiation | MAPK12;PIK3CG;NFATC1;FCGR4;LCK;SIRPA;PIK3CD;NCF4;PPP3R1 |
PI3K-Akt signaling pathway | PRP2;CSF1R;CSF3;CSH2;EFNA2;CHAD;LAMC3;LOC608458;CDC37 |
Pathways in cancer | BIRC5;FGFR1;STAT1;IGF1;ARAF;WNT8B;APC2;RARA;Pdgfa&Pdgfb |
CSF1R has several biochemical functions, for example, ATP binding, cytokine binding, macrophage colony-stimulating factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1R itself. We selected most functions CSF1R had, and list some proteins which have the same functions with CSF1R. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | UBE2IB;SCYL2;TOR1;CAMKK2;PIP5KL1;IP6K2;SMARCA5;Abca2;RARS2 |
cytokine binding | PARK7;CSF1R;ELANE;KITA;CD74;NRP1;IFNGR1;KITB;Fzd4 |
macrophage colony-stimulating factor receptor activity | CSF1R;MST1R |
protein homodimerization activity | CAT;SRF;DMRTB1;PRPS1;PTPRO;SEPHS1;YARS2;SPATA24;NRF1 |
protein phosphatase binding | IRS2;KCNN4;MAP2K7;TP53;MAP3K5;CDKN1B;AP3B1;GRB2;JAK3 |
CSF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1R.
Plcg2; saicar; PKM; GRAP2; HSP90AB1; PIK3R1; yqeH; hppD; purL; Src; FYN; Fyn; Yes1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.
CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.
Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.
CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.
Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.
Customer Reviews (3)
Write a reviewWith its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.
This variety allows me to select the most appropriate option based on the specific requirements of my research.
the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.
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