Active Recombinant Human CSF1R Protein, GST-tagged
Cat.No. : | CSF1R-1964H |
Product Overview : | Human CSF1R (NP_005202.2, 538 a.a. - 972 a.a.) partial recombinant protein with GST tag expressed in Baculovirus infected Sf21 cells. |
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Description : | The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017] |
Source : | Insect Cells |
Species : | Human |
Tag : | GST |
Form : | Liquid |
Bio-activity : | The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg (or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.Substrate : Srctide. ATP: 100 µM. |
Molecular Mass : | 76 kDa |
Purity : | 77 % by SDS-PAGE/CBB staining. |
Applications : | Functional Study SDS-PAGE |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol) |
Protein length : | 538-972 |
Gene Name : | CSF1R colony stimulating factor 1 receptor [ Homo sapiens ] |
Official Symbol : | CSF1R |
Synonyms : | CSF1R; colony stimulating factor 1 receptor; FMS, McDonough feline sarcoma viral (v fms) oncogene homolog; macrophage colony-stimulating factor 1 receptor; C FMS; CD115; CSFR; CSF-1-R; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; FMS; FIM2; HDLS; C-FMS; CSF-1R; M-CSF-R; |
Gene ID : | 1436 |
mRNA Refseq : | NM_005211 |
Protein Refseq : | NP_005202 |
MIM : | 164770 |
UniProt ID : | P07333 |
Products Types
◆ Recombinant Protein | ||
CSF1R-1320S | Recombinant Human CSF1R Protein (Y538-C972), GST tagged | +Inquiry |
CSF1R-180H | Recombinant Human CSF1R Protein, His (Fc)-Avi-tagged | +Inquiry |
CSF1R-1965H | Recombinant Human CSF1R Protein, GST-tagged | +Inquiry |
Csf1r-1966M | Recombinant Mouse Csf1r Protein, GST-tagged | +Inquiry |
CSF1R-020H | Recombinant Human CSF1R Protein, C-His-tagged | +Inquiry |
◆ Lysates | ||
CSF1R-444HCL | Recombinant Human CSF1R cell lysate | +Inquiry |
CSF1R-823RCL | Recombinant Rat CSF1R cell lysate | +Inquiry |
CSF1R-2739HCL | Recombinant Human CSF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1574 | CSF1R Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWith its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.
This variety allows me to select the most appropriate option based on the specific requirements of my research.
the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.
Q&As (5)
Ask a questionYes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.
CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.
Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.
CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.
Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.
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