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CTGF

  • Official Full Name

    connective tissue growth factor

  • Overview

    The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
  • Synonyms

    CTGF; connective tissue growth factor; CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus macaque
  • Sheep
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Protein Conjugation
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • His
  • DDK
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTGF-555H Active Recombinant Human Connective Tissue Growth Factor E.coli N/A
Human CTGF-28023TH Recombinant Human CTGF E.coli N/A
Human CTGF-29H Recombinant Human CTGF, 182-250aa, His-tagged E.coli His
Human CTGF-16H Recombinant Human CTGF, His-tagged E.coli His 27-349aa
Human CTGF-2605H Recombinant Human CTGF, His-tagged HEK293 His 329aa
Human CTGF-2606H Recombinant Human CTGF, Fc-tagged Human Cell Fc
Human CTGF-852H Recombinant Human CTGF Protein, DDK-tagged Sf9 Insect Cell DDK
Human CTGF-2069H Recombinant Human CTGF Protein, GST-tagged Wheat Germ GST
Human CTGF-30H Recombinant Human Connective Tissue Growth Factor, His-tagged E.coli His
Human CTGF-7205HCL Recombinant Human CTGF 293 Cell Lysate HEK293 N/A
Human CTGF-301121H Recombinant Human CTGF protein, GST-tagged E.coli GST Leu80-156Leu
Human CTGF-2466H Recombinant Human CTGF protein, His-tagged E.coli His 297-349 aa
Human CTGF-2604H Active Recombinant Human CTGF protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln 27 - Ala 349
Human CTGF-391H Recombinant Human CTGF Protein, His & Avi-tagged, Unconjugated HEK293 His/Avi Gln 27 - Ala 349
Human CTGF-2607H Active Recombinant Human CTGF protein, Fc-tagged HEK293 Fc Gln27-Ala349
Human CTGF-1287H Recombinant Human CTGF Protein, His&GST-tagged E.coli N-His&GST Gln27-Ala349
Human CTGF-392H Recombinant Human CTGF protein, His-tagged HEK293 His 323
Human CTGF-2554H Recombinant Human CTGF protein, His-tagged E.coli His 80-156 aa
Human CTGF-4046H Recombinant Human CTGF Protein (Met1-Ala349), C-Fc tagged Mammalian cells C-Fc Met1-Ala349
Human CTGF-2795H Recombinant Human CTGF Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Asp99-Arg111
Human CTGF-4047H Recombinant Human CTGF Protein (Met1-Ala349), C-His tagged Mammalian cells C-His Met1-Ala349
Human CTGF-2277HF Recombinant Full Length Human CTGF Protein, GST-tagged In Vitro Cell Free System GST 251 amino acids
Human CTGF-1865H Recombinant Human CTGF Protein (Gln27-Ala349), C-Fc tagged Mammalian cells C-Fc Gln27-Ala349
Mouse Ctgf-541M Recombinant Mouse Ctgf protein, His-tagged E.coli His Leu245~Asp346
Mouse Ctgf-2744M Recombinant Mouse Ctgf Protein, GST-tagged E.coli GST
Mouse CTGF-4022M Recombinant Mouse CTGF Protein Mammalian Cell His
Mouse CTGF-2051M Recombinant Mouse CTGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CTGF-393M Recombinant Mouse CTGF protein, His-tagged HEK293 His 323
Mouse CTGF-2051M-B Recombinant Mouse CTGF Protein Pre-coupled Magnetic Beads HEK293
Rat CTGF-1654R Recombinant Rat CTGF Protein Mammalian Cell His
Rat Ctgf-544R Recombinant Rat Ctgf protein, His-tagged E.coli His Gln25~Ala347
Rat CTGF-1313R Recombinant Rat CTGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTGF-1313R-B Recombinant Rat CTGF Protein Pre-coupled Magnetic Beads HEK293
Rabbit CTGF-865R Recombinant Rabbit CTGF Protein, His-tagged E.coli N-His Leu118-Ala388
Cattle CTGF-538C Recombinant Cattle CTGF protein, His & T7-tagged E.coli His/T7 Ala101~Pro330 (Accession # O18739)
Rhesus macaque CTGF-2982R Active Recombinant Rhesus macaque CTGF protein, His-tagged HEK293 His Gln 27-Ala 349
Sheep CTGF-542S Recombinant Sheep CTGF protein, His-tagged E.coli His Ala101~Pro330 (Accession # C7EDS5)
Pig CTGF-543P Recombinant Pig CTGF protein, His-tagged E.coli His Ala101~Pro330 (Accession # O19113)
Chicken CTGF-5847C Recombinant Chicken CTGF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTGF Related Articles
  • CTGF Related Research Area

CTGF involved in several pathways and played different roles in them. We selected most pathways CTGF participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid, triacylglycerol, and ketone body metabolismMED26;MED21;SIN3B;GLIPR1;GRHL1;MTF1;CPT2;ESRRA;MED9
Gene ExpressionRPP30;ZNF41;HELZ2;GATAD2B;ARHGEF38;MAEL;CLP1;SETB;NR4A2A
Generic Transcription PathwayZFP30;ZNF75D;CCNC;ZNF212;ZNF530;RNF111;ZNF460;ZNF529;ZNF705A
Hippo signaling pathwayPPP2R2C;LEF1;CTNNA3;PARD3;FRMD6;FZD2;SAV1;TGFB3;SMAD2
MetabolismCA13;ADSSL1;PITPNB;APOA4A;SLC5A4;PLIN2;GC;ADK;NAALAD2
Metabolism of lipids and lipoproteinsDGAT1B;PTPMT1;SLC27A5;PPARGC1B;CLPS;DPEP1;ARF3;GLIPR1;ACOT6
PPARA activates gene expressionG0S2;MED9;MED25;MED16;MED21;MED26;MED8;GRHL1;MED6
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)MED9;MED18;MED31;MED7;MED15;G0S2;MED10;MED6;MED26

CTGF has several biochemical functions, for example, fibronectin binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTGF itself. We selected most functions CTGF had, and list some proteins which have the same functions with CTGF. You can find most of the proteins on our site.

Function Related Protein
fibronectin bindingLRRC15;VEGFA;ITGB1;SDC4;FBLN1;IGFBP5B;ITGAV;IGFBP5;IGFBP3
growth factor activityBMP6;TDGF1;CSF3;SPAW;FGF13;AMELX;FGF10B;CSPG5;CECR1A
heparin bindingCXCL10;NOV;FGF14;ADAMTS1;MMP7;ZNF207;IMPG2;THBS4;FGF1A
insulin-like growth factor bindingIGFBP3;IGF1RB;WISP1A;KAZALD2;HTRA4;IGFALS;CTGFB;HTRA1B;IGFBP6A
integrin bindingESM1;FBN1;CTGFA;EGFL6;CTGFB;ITGA3;VCAM1;ITGA6;LAMA5
protein C-terminus bindingPDZD3;NCF2;NEFL;OPRL1;PEX1;SHANK3;SLC4A1;TJP2;DST
protein bindingHSPA8;ERAL1;GAPDHS;POT1A;SPATA2;TRIM63;MCM4;TAF8;LGR6

CTGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTGF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTGF.

FN1; FGFR1OP; FGFR2; FGFR3; LIMS1; q81kk8_bacan; lonB; q81tk4_bacan; rpoB; gnd; nemA; mdtB; rnhA; q9wmx2-pro_0000037548; ITGA5

Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
Gao, W; Cai, LT; et al. Anti-CTGF Single-Chain Variable Fragment Dimers Inhibit Human Airway Smooth Muscle (ASM) Cell Proliferation by Down-Regulating p-Akt and p-mTOR Levels. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How can CTGF be measured or detected in clinical settings? 12/20/2017

CTGF levels can be measured using various techniques, including enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry.

What are the potential diagnostic applications of CTGF in medicine? 07/18/2017

CTGF levels can serve as diagnostic markers for fibrotic diseases, aiding in the early detection and monitoring of such conditions.

Are there therapeutic implications of targeting CTGF in clinical practice? 03/08/2017

Yes, targeting CTGF is being explored as a potential therapeutic strategy to mitigate fibrosis in various organs and tissues.

In which medical specialties is CTGF protein research particularly relevant? 11/18/2016

CTGF protein research is particularly relevant in specialties such as rheumatology, pulmonology, and dermatology due to its implications in fibrotic diseases.

How does CTGF contribute to fibrosis? 09/13/2016

CTGF plays a crucial role in promoting the formation of fibrous tissue by stimulating the production of extracellular matrix proteins.

Customer Reviews (3)

Write a review
Reviews
03/22/2021

    Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.

    08/06/2019

      With their assistance, I can overcome obstacles and optimize my experimental setup.

      09/23/2018

        With the CTGF protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.

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