DEFB4A
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Official Full Name
defensin, beta 4A
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Overview
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. -
Synonyms
DEFB4A; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2; SAP1; BD-2; beta-defensin 4A; defensin, beta 2; defensin, beta 4; skin-antimicrobial peptide 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E.coli
- HEK293
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- DEFB4A Related Research Area
DEFB4A involved in several pathways and played different roles in them. We selected most pathways DEFB4A participated on our site, such as Beta defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFB4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Beta defensins | DEFB103A;DEFB119;DEFB1;DEFB106A;DEFB4A;DEFB116;CCR6;DEFB125;DEFB4B |
Defensins | DEFB1;DEFA3;CCR6;DEFA1;DEFB104A;DEFB4A;DEFB119;DEFB4B;DEFB121 |
Immune System | DUSP3;UBR1;TRIM45;BST2;PELI3;BTR18;LTF;TRIM46;LRR1 |
Innate Immune System | DEFB4A;PLD4;DDX41;DEFB4B;MYO1C;MB21D1;LAT2;CTSK;BTR22 |
DEFB4A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFB4A itself. We selected most functions DEFB4A had, and list some proteins which have the same functions with DEFB4A. You can find most of the proteins on our site.
Function | Related Protein |
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DEFB4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFB4A here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFB4A.
- Q&As
- Reviews
Q&As (6)
Ask a questionDEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.
Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.
The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.
Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.
The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.
There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.
Customer Reviews (3)
Write a reviewThe structure is very stable and not easy to deteriorate.
The cost is low and the activity is strong, which greatly saves our scientific research costs.
The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.
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