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Ihh

  • Official Full Name

    indian hedgehog

  • Overview

    This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
  • Synonyms

    IHH; indian hedgehog; BDA1; HHG2; indian hedgehog protein; HHG-2; Indian hedgehog homolog;

  • Recombinant Proteins
  • Chicken
  • Human
  • Human/Mouse
  • Mouse
  • E.coli
  • Mammalian Cell
  • His
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IHH-7884H Recombinant Human IHH protein, His-tagged E.coli His Phe240~Gly399 (Accession # Q14623)
Human IHH-656H Recombinant Human IHH protein E.coli N/A 176
Human IHH-1673H Recombinant Human IHH protein, His & T7-tagged E.coli His/T7 Val45~Ser195 (Accession # Q14623)
Human IHH-372I Active Recombinant Human IHH Protein (178 aa) E.coli 178
Human IHH-3104H Recombinant Human IHH Protein (Phe240-Gly399), His tagged E.coli His Phe240-Gly399
Human IHH-4428H Recombinant Human IHH protein, His-tagged E.coli His 203-411aa
Mouse Ihh-1892M Active Recombinant Mouse Indian Hedgehog E.coli N/A
Human/Mouse IHH-124H Recombinant Human/Mouse IHH Protein E.coli
Human/Mouse IHH-125H Recombinant Human/Mouse IHH Protein E.coli
Human/Mouse IHH-126H Recombinant Human/Mouse IHH Protein E.coli
Chicken IHH-6516C Recombinant Chicken IHH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ihh Related Articles
  • Ihh Related Research Area

Ihh involved in several pathways and played different roles in them. We selected most pathways Ihh participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ihh were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayWNT1;LRP2;RAB23;WNT7B;IHH;SAP18;WNT7AA;ZIC2;GLI2B

Ihh has several biochemical functions, for example, calcium ion binding, patched binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ihh itself. We selected most functions Ihh had, and list some proteins which have the same functions with Ihh. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCUBN;PCDHGB2;EHD4;EFCAB10;CETN1;PRRG1;LALBA;CD248;SYT1
patched bindingShh;IHH;SMO;CAV1;PTCH1;SETD6;CCNB1;BBS1;DHH
peptidase activityMETAP2A;PRSS48;PSMB9B;Gzmg;CTSL1B;PRSS40;CAPN8;FURINA;USPL1

Ihh has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ihh here. Most of them are supplied by our site. Hope this information will be useful for your research of Ihh.

RHOD

Kebenko, M; Drenckhan, A; et al. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. CELLULAR SIGNALLING 27:373-381(2015).
Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
  • Q&As
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