JUN
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Official Full Name
jun proto-oncogene
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Overview
Transcription factor AP-1; JUN; AP-1; AP1; c-Jun; jun proto-oncogene; p39; jun oncogene; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog -
Synonyms
JUN; jun proto-oncogene; jun oncogene ,v jun avian sarcoma virus 17 oncogene homolog ,v jun sarcoma virus 17 oncogene homolog (avian); transcription factor AP-1; AP 1; c Jun; Activator Protein 1; AP 1; AP1; cJun; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN; Jun oncogene; JUN protein; Jun proto oncogene; JUN_HUMAN; JUNC; Oncogene JUN; p39; Proto oncogene c jun; Proto oncogene cJun; Proto-oncogene c-jun; Transcription Factor AP 1; Transcription factor AP-1; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; V jun sarcoma virus 17 oncogene homolog (avian); V-jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; p39; jun oncogene; OTTHUMP00000010036; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog; AP1; AP-1; c-Jun;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|MBP
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- JUN Related Articles
- JUN Related Research Area
- JUN Related Signal Pathway
JUN involved in several pathways and played different roles in them. We selected most pathways JUN participated on our site, such as AGE/RAGE pathway, ATF-2 transcription factor network, Activated TLR4 signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AGE/RAGE pathway | LGALS3;EGFR;JAK2;TIRAP;DIAPH1;MMP13;MAPK14;DDOST;JUN |
ATF-2 transcription factor network | JUND;JUN;CREB1;DUSP10;DUSP5;DUSP1;GADD45A;CBFB;JDP2 |
Activated TLR4 signalling | NOD1;MAP3K8;PELI1;MAPKAPK2B;SIGIRR;TANK;TICAM1;ALCAMB;DHX9 |
Activation of the AP-1 family of transcription factors | ATF2;JUN;MAPK14 |
AhR pathway | AHRR;JUND;FLG;CYP1B1;CYP1A1;AIP;EGFR;JUN;CDKN1B |
Androgen receptor signaling pathway | PIAS3;ZMIZ1;ETV5A;POU2F1B;NR2C2;RNF4;PATZ1;CARM1;KDM1A |
Apoptosis | BCL2A;IL1B2;CYCS;BADB;BCL2;NFKBIAB;FADD;PRKAR2A;IL1A |
JUN has several biochemical functions, for example, DNA binding, GTPase activator activity, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUN itself. We selected most functions JUN had, and list some proteins which have the same functions with JUN. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | GLI1;MIER1;ZFP354A;SOS1;PBRM1;HOXC13A;ZFP37;NFE2L2A;ZNF124 |
GTPase activator activity | BCR;ACAP1;ARHGAP40;CDC42EP2;TBC1D26;TBC1D22B;TBC1D5;PLCB1;GAPVD1 |
HMG box domain binding | HHEX;ALX4;PRRX1;MEOX1;GATA3;SP1;HOXA3;HOXC4;DLX5 |
R-SMAD binding | RANBP3;ANKRD1;MEN1;FOS;PAX6;SMAD3;TRIM33;ZEB2;MYOCD |
RNA polymerase II activating transcription factor binding | DUSP26;LMO2;TP53BP1;HIPK2;NCOR1;EGR2;SIN3A;ZFPM1;BHLHE40 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | BCL11A;ETV6;TCF3;ELK3;GRHL1;EBF2;HINFP;TCF3B;GMEB1 |
RNA polymerase II distal enhancer sequence-specific DNA binding | POU4F1;SOX10;T;MSC;NR1H4;H2AFZ;SFPI1;FLI1;NFATC1 |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | RUNX2;ELF3;SOX8;GCM1;ZNF488;ATF4;TFDP2;ZSCAN18;TAL1 |
cAMP response element binding | JUN;ATF6;CREB3L3L;CREB1;CREB3L2;CREB3L3A;CREB3;HMGA2;CREB3L3 |
chromatin binding | NFATC2;ANKRD2;TGIF1;HMGB3;MEN1;CSNK2B;YBX2;TRIM37;POLR2B |
enzyme binding | YWHAH;IL6R;GRIN1;CBX4;HOXA9;CYP2A4;TNKS2;CCND1;MAPK8 |
poly(A) RNA binding | HSPB1;RBM26;HADHB;PCBP4;NXF2;PPP1R10;SLC16A3;MRPS11;TNPO1 |
protein binding | STAR;HESX1;HHLA2;USP17L2;BMPR1AA;ZBTB16;EXOC3L;RND1;TAF1D |
transcription coactivator activity | RIPK3;NR1H3;TAF6L;SUB1;GTF2F1;NR5A1;PRRX1;WWTR1;MKL1B |
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | GATA5;PURA;FOXF1;IRF8;THRA;POU4F1;NR5A2;TEAD2;MEIS1 |
transcription factor activity, sequence-specific DNA binding | ZFP354B;WT1B;TRIM22;FOXE1;ZNF317;ZNF157;ATF1;SOX13;NFE2L1A |
transcription factor binding | ATOH8;HES4;JUND;DNAJA3;NKX2;GPX3;NFKB1;DIP2A;HES6 |
transcription regulatory region DNA binding | RFX6;WNT1;KLF1;NFE2L2;RREB1;GATA3;PHB;CTNNB1;TP73 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FIGLA;TRP63;MAFB;NR4A3;HIF1A;TLX1;ETV6;POU2F3;NFAT5 |
transcriptional activator activity, RNA polymerase II transcription factor binding | CLOCK;CREB1;PPARA;NKX2;PITX1;NOTCH1;WWP2;MIXL1;MED12 |
JUN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUN here. Most of them are supplied by our site. Hope this information will be useful for your research of JUN.
FOS
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are currently no drugs that directly regulate the expression level of JUN, but some JUN-related diseases can be treated by inhibiting its activity or regulating its expression.
JUN has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
Mutations in JUN can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
The types of mutations in JUN include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Studying the regulatory mechanism of JUN requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
JUN plays an important role in the cell cycle, which can promote the transition of cells from G1 phase to S phase and promote cell proliferation and differentiation.
Customer Reviews (3)
Write a reviewThe stability of the protein indicates ease of storage.
High biological activity.
Highly expressed in the expression system.
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